沙格雷酯对糖尿病足病人血清胆红素及炎症因子水平的影响

Effect of sarpogrelated on serum bilirubin and inflammatory factors in patients with diabetic foot

目的:探讨沙格雷酯对糖尿病足(DF)病人血清胆红素及炎症因子水平的影响。方法:选取80例DF病人随机分为观察组和对照组,各40例。对照组进行基础治疗,治疗组在对照组基础上加用沙格雷酯。6个月后观察并记录病人的血清胆红素以及炎症因子水平,并评价各组病人治疗效果。结果:随着治疗的进行2组病人血管细胞黏附分子-1和成纤维细胞生长因子-2均水平有所降低,且观察组治疗后6个月血管细胞黏附因子-1和成纤维细胞生长因子-2水平均低于对照组(P<0.01和P<0.05)。随着治疗的进行,2组病人肿瘤坏死因子-α和白细胞介素-6水平有所降低,且观察组治疗后6个月细胞坏死生长因子-α和白细胞介素-6水平低于对照组(P<0.05和P<0.01),2组病人总胆红素、间接胆红素水平有所升高,且观察组病人升高程度高于对照组(P<0.05)。2组病人临床疗效比较差异有统计学意义(P<0.05)。结论:沙格雷酯治疗DF能有效改善病人血清炎症因子,提高胆红素水平,提高治疗效果。

Objective： To investigate the effect of sarpogrelated on serum bilirubin and inflammatory factor level diabetic foot（ DF）.Methods： Eighty cases of DF patients were randomly divided into observation group and control group,each group of 40 cases. The control group was treated with basic treatment,while the treatment group was treated with sarpogrelated. After 6 months,the serum bilirubin and inflammatory factors were observed and recorded. Results： With the treatment,VCAM-1 and FGF2 of all patients were significantly decreased,and at 6 months after treatment,the VCAM-1 and FGF2 levels in observation group was lower than those in the control group（ P〈0. 01 and P〈0. 05）,with the treatment,TNF-α and IL-6 levels of all patients with were decreased,but at 6 months after treatment,TNF-α and IL-6 level in the observation group was lower than those in the control group（ P〈0. 05 and P〈0. 01）,with the treatment,TBIL,IBIL level of 2 groups has been restored,but at 6 months after treatment,the TBIL,IBIL level of observation group was significantly higher that of the control group（ P〈0. 05）,the total efficiency of observation group was significantly higher than that of the control group,with significant difference between the two groups（ P〈0. 05）. Conclusions： Sarpogrelated can effectively improve the serum inflammatory factors,improve the level of bilirubin and improve the therapeutic effect.