摘要
目的:探讨LEA在大肠癌中的表达及意义。方法:采用免疫组织化学S-P法检测140例大肠癌组织和100例大肠非癌组织LEA与CEA的表达。结果:LEA表达与肿瘤分化程度有相关性,对高分化腺癌表现出更高的选择性(P<0.01),CEA单抗对高、中、低分化腺癌选择性相似(P>0.05),LEA在腺瘤中表达的阳性率,明显高于癌旁粘膜和正常粘膜;LEA在正常粘膜标记的阳性率明显低于CEA(P<0.05)。结论:LEA的表达与大肠癌组织的分化程度有关,LEA可作为大肠癌早期诊断的辅助指标。
Objective:To probe into the expression and the clinic significance of LEA on colorectal carcinoma. Methods:The expression of LEA and CEA in 140 colorectal cancer specimens and 100 colorectal non-cancerous specimens had been detectd by immunohistcchemistry S-P method.Results:The expression of LEA was relative to tumor differentiation degree and exhibits higher selectivity in high differentiation ade-nocarcinoma ( P < 0.01) . CEA had similar selectivity in well, moderately and poorly differentiated adenocarcinoma ( P > 0.05) . The positive rate of LEA in adenoma was much higher than surrounding non-cancerous mucosa and normal mucosa. In normal mucosa the positive rate of LEA was obviously lower than that of CEA ( P < 0.05). Conclusion: The expression of LEA is related to the differentiation degree of colorectal carcinoma tissue . LEA can be used as an auxiliary index of early diagnosis of colorectal carcinoma.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2002年第8期539-542,共4页
Chinese Journal of Immunology
基金
国家科技部中试开发项目
关键词
大肠癌相关抗原
LEA
诊断
Colorectal cancer Colorectal carcinoma-associated antigen Large external antigen (LEA) Diagnosis