脂联素联合瘦素在结直肠癌高危人群中的诊断价值

Diagnosis Value of Combining Adiponectin and Leptin in High Risk Population with Colorectal Cancer

目的:探讨脂联素(Adiponectin,ADPN)联合瘦素(Leptin,LP)在结直肠癌高危人群中的诊断价值。方法:选取2016年6月-2017年4月本院收治的结直肠癌患者50例作为A组,于同期另选取50例健康体检者作为B组,测定两组血清ADPN和LP水平,应用受试者工作特征(Receiver Operating Characteristic curve,ROC)曲线分析血清ADPN和LP对结直肠癌的诊断效能。结果:A组血清ADPN水平明显低于B组,差异有统计学意义(P<0.05);A组血清LP水平明显高于B组,差异有统计学意义(P<0.05);ROC曲线显示,两项联合对结直肠癌的敏感度和特异度最高,约登指数和曲线下面积最大。结论:联合检测脂联素联合瘦素有助于提高结直肠癌的检出率。

Objective：To discuss the diagnosis value of combining Adiponectin（ADPN） and Leptin（LP） in high risk population with colorectal cancer.Method：A total of 50 patients with colorectal cancer from June 2016 to April 2017 were selected as A group,and 50 cases of health examiner were selected as B group.The serum levels of ADPN and LP were detected.ROC curve was used to analyze the evaluate the diagnostic efficiency of ADPN combined with LP measured in the study subjects.Result：Serum levels of ADPN in A group was lower than that of B group（P〈0.05）.Serum levels of LP in A group was higher than that of B group（P〈0.05）.ROC curve showed：the sensitivity,specificity,Youden index and AUC of ADPN＋LP was the highest.Conclusion：The combined screening of ADPN and LP can significantly improve the detection rate of colorectal cancer.