血清性激素水平与围绝经期女性代谢综合征的关系

Relationship between serum sex hormones levels and metabolic syndrome of women in perimenopause period

目的探讨血清性激素水平与围绝经期女性代谢综合征(MS)的关系。方法收集2016年1月~2017年6月在本中心妇科门诊就诊及居民健康体检中符合本研究要求的290名女性作为观察对象,参照STRAW分期标准分为绝经前期、绝经过渡期、绝经早期和绝经晚期四组,并根据2013年中国糖尿病指南MS诊断标准来确定是否患有MS,分析围绝经期女性MS与血清性激素水平的关系。结果绝经前期组、绝经过渡期组、绝经早期组和绝经晚期组的MS患病率分别为18.67%、19.51%、29.69%、39.13%,呈上升趋势。绝经过渡期组、绝经早期组和绝经后期组MS患者的血清FSH水平高于正常者,差异有统计学意义(P<0.05或<0.01);绝经过渡期组、绝经后期组MS患者的LH水平高于正常者,差异有统计学意义(P<0.05);绝经早期组和绝经晚期的血清E2水平明显降低,差异有统计学意义(P<0.05或<0.01)。结论绝经后女性患MS的风险增加,血清中E2水平的变化对MS的发生与发展起着重要作用,但相关机制仍有待进一步研究。

Objective To investigate the relationship between serum sex hormones levels and metabolic syndrome（MS）of women in perimenopause period. Methods From January 2016 to June 2017, a total of 290 women who were in line with the requirements of the study in the gynecology clinic and the residents′ health examination were selected as observers. According to STRAW staging criteria, all observers were divided into premenopausal group, menopausal transition group, early menopause group and late menopause group. MS was defined according to the diagnostic criteria of metabolic syndrome in Chinese Diabetes 2013, the relationship between serum sex hormones levels and MS of women in different stage of perimenopause was analyzed. Results The prevalence rates of MS in premenopausal group,menopausal transition group, early menopause group and late menopause group were 18.67%, 19.51%, 29.69% and39.13%, it was on the rise. The FSH serum level of MS patients in menopausal transition group, early menopause group and late menopause group were significantly higher than that of the normal person（P〈0.05 or 0.01）. The LH serum level of MS patients in the menopausal transition group and late menopause group were higher than that of the normal person（P〈0.05）. The E2 serum level of MS patients in early menopause group and late menopause group were significantly lower than that of the normal person（P〈0.05 or 0.01）. Conclusion The risk of MS increase in postmenopausal women. The change of serum E2 level in postmenopausal women play an important role in the occurrence and development of MS. However, the related mechanism remains to be further studied.