细针穿刺标本Midkine检测在甲状腺微小乳头状癌中的临床意义

Clinical significance of fine-needle aspiration specimen Midkine detection in papillary thyroid microcarcinoma

目的探讨细针穿刺标本Midkine检测在甲状腺微小乳头状癌中的临床意义。方法选取2014年8月~2017年5月我院收治的50例甲状腺微小乳头状癌患者、30例结节性甲状腺肿患者的术中细针穿刺标本作为研究对象,观察两类病理类型免疫细胞化学技术检测Midkine的表达。结果甲状腺微小乳头状癌细针穿刺标本Midkine的表达明显高于结节性甲状腺肿,差异有统计学意义(P<0.01)。有淋巴结转移甲状腺微小乳头状癌患者的细针穿刺标本Midkine表达阳性率高于无淋巴结转移患者,差异有统计学意义(P<0.05)。结论检测细针穿刺标本Midkine的表达可为甲状腺微小乳头状癌的正确诊断和淋巴结转移预测提供帮助。

Objective To investigate the clinical significance of fine-needle aspiration specimen Midkine detection in papillary thyroid microcarcinoma. Methods Fine-needle aspiration specimens from 50 patients with papillary thyroid microcarcinoma and 30 patients with thyroid nodular goiter who were admitted to our hospital and underwent surgery from August 2014 to May 2017 were selected as objects. Immunocytochemical expression of Midkine was observed in fine-needle aspiration specimens from above patients. Results Fine-needle aspiration specimen Midkine expression of papillary thyroid microcarcinoma was significantly higher than that of thyroid nodular goiter, and the difference was statistically significant（P〈0.01）. The positive rate of Midkine expression in patients with lymph node metastasis of papillary thyroid microcarcinoma was higher than that of patients without lymph node metastasis, and the difference was statistically significant（P〈0.05）. Conclusion The detection of fine-needle aspiration specimen Midkine is helpful in the diagnosis of papillary thyroid microcarcinoma and the prediction of lymph node metastasis.