心血管疾患血浆ANF和PRA、AT-Ⅱ、ALD变化的临床意义

Determination and clinical significance analysis of ANF、PRA、AT-Ⅱ and ALD in the heart failure patients

目的:为了解心血管疾患及心衰患者的血浆心钠素（ANF）和肾素（PRA）、血管紧张素Ⅱ（AT-Ⅱ）、醛固酮（ALD）水平的变化。方法:对163例心血管疾患及其中51例心衰患者经心肌血管紧张素转换酶抑制剂参麦注射液的应用,对治疗前后体内调节水盐代谢的二大重要激素系统进行放射免疫的定量分析。结果:急性心肌梗死、风心病、肺心病及高心病患者血浆ANF和PRA、AT-Ⅱ、ALD值明显高于对照组（P<0.05）。而心肌炎及心肌缺血庸者以上指标略高于对照组（P>0.05）。各类心血管疾患发生心衰组与无心衰组比差异显著（P<0.01）。加用参麦注射液治疗2w后,心衰组随病情的改善、心功能的好转,各指标与治疗前比均有不同程度下降,与自身治疗前比ANF、AT-Ⅱ、ALD分别降低32.5％、25.3％、27.1％,ANF与RSSA系统下降幅度显呈著正相关关系。结论:ANF、PRA、AT-Ⅱ、ALD联合检测有助于心血管疾病患者及心功能不全的诊疗观察,是有实用价值的辅助诊断。

Objective:To investigate the effect of ANF, PRA, AT-α and ALD on the occurrence of Heart failure patients and Congestive heart failure(CHF) .Methods:The plasma were measured by radioimmunoassay(RIA) in 163 patients(112 on heart failure patients,51 congestive heart failure)before and after taking Angiotensiin converting enzyme. The results were as foron: ll. Results:The concentrations of ANF, PRA,AT-α and ALD in acute myocardid infarction, Rheumatic valvuar disease, cor pulmonale and Hypertension patients were higher significantly than the contorl group(heart failure)( P < 0.05) .The concentration of ANF,RPA, AT-α and ALD in myocarditis and myocarcliul ischemia were higher lightly than the control group( P > 0.05) .After taking ACE inhibitor,AT an extent, the values were decreased-ANF 32.5%, AT-α 25.3 % and ALD 27.1 % , A positive correlation was shown between ANF system and RSSA system. Conclusion: The results suggested that monitoring of ANF,PRA,AT-α and AID with RIA technique showed a beneficial to heart's disease and heart's dysfunction.