摘要
牛磺熊去氧胆酸(tauroursodeoxycholic acid,TUDCA)是由牛磺酸连接熊去氧胆酸(ursodeoxycholic acid,UDCA)形成,具有抗炎、抗凋亡、降低胶原细胞激活的作用,而这些作用皆可能成为延缓视网膜色素变性(retinitis pigmentosa,RP)病理过程最关键的环节。研究证明,TUDCA对RP有潜在的治疗价值,本文就TUDCA治疗RP的机制研究进展进行综述。
Tauroursodeoxycholic acid（ TUDCA） is formed by taurine conjugated of ursodeoxycholic acid（ UDCA）. It has the role of neurotrophic factor in anti-inflammatory,anti-apoptosis and reducing the activation of microglial cells. These effects may be one of the most critical of all pathological stages of retinitis pigmentosa. Preclinical trials have shown that TUDCA had potential therapeutic value for retinal degeneration disease. This article discusses how TUDCA can slow down the process of retinal degeneration.
作者
袁莉
刘焰
Li Yuan;Yan Liu(Shanghai General Hospital,School of Medicine,Shanghai Jiaotong Universit;Shanghai Key Laboratory of Ocular Fundus Disease;Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai 200080,Chin)
出处
《国际眼科杂志》
CAS
北大核心
2018年第8期1403-1406,共4页
International Eye Science
基金
国家自然科学基金面上项目(No.81371068)~~
关键词
牛磺熊去氧胆酸
视网膜色素变性
凋亡
氧化应激
胶原激活
tauroursodeoxychol ic acid
retini tis pigmentosa
apoptosis
oxidative stress
microglial cell activation
