不同剂量应用瑞舒伐他汀治疗老年冠心病并高脂血症的临床疗效

Clinical Efficacy of Different Doses of Rosuvastatin in Elderly Patients with Coronary Heart Disease and Hyperlipidemia

目的了解应用不同剂量的瑞舒伐他汀治疗老年冠心病并高脂血症的疗效。方法以随机法将方便选取该院2014年1月—2017年12月收治的102例老年冠心病并高脂血症分成2组:予与小剂量瑞舒伐他汀(10 mg/d)治疗的51例作对照组,予以大剂量瑞舒伐他汀(10 mg/d)治疗的51例作研究组,对比2组疗效。结果 51例研究组的有效率为96.08%(49/51),较51例对照组的78.43%(40/51)相比,差异有统计学意义(χ2=7.141,P=0.008);研究组给药后TG(1.53±0.11)mmol/L、LDL-C(2.62±0.22)mmol/L、HDL-C(0.98±0.16)mmol/L等,明显优于对照组(2.20±0.13)、(3.21±0.15)、(0.81±0.13)mmol/L,(t=-28.097、-15.824、5.889,P<0.05)。结论临床治疗老年冠心病并高脂血症,选用大剂量瑞舒伐他汀治疗的效果确切,可在提升治疗效果的同时,改善机体血脂水平。

Objective This paper tries to understand the effect of different doses of rosuvastatin on elderly patients with coronary heart disease and hyperlipidemia. Methods 102 patients with coronary heart disease complicated with hyperlipidemia treated in this hospital from January 2014 to December 2017 were convenient selected and randomly divided into two groups： 51 patients treated with low-dose rosuvastatin（10 mg/d） were used as control group, 51 patients treated with highdose rosuvastatin（10 mg/d） were included in the study group to compare the efficacy of the two groups. Results The effective rate of the 51 study groups was 96.08%（49/51）, which was significantly different from that of the 51 control subjects（78.43%（40/51）（χ2=7.141,P=0.008）; the study group was administrated after treatment, TG（1.53 ±0.11）mmol/L, LDL-C（2.62±0.22） mmol/L, and HDL-C（0.98±0.16） mmol/L, etc. were significantly better than the control group（2.20±0.13）,（3.21±0.15）,（0.81 ±0.13） mmol/L,（t =-28.097,-15.824,5.889,P〈0.05）. Conclusion Clinical treatment of elderly patients with coronary heart disease and hyperlipidemia, the use of high-dose rosuvastatin treatment of the exact effect, can improve the therapeutic effect at the same time, improve the body＇s blood lipid levels.