凝血指标及D-二聚体对妊娠高血压的诊断价值

Coagulation Index and D-Dimer's Diagnostic Value for Pregnancy-induced Hypertension

目的探讨凝血指标及D-二聚体对妊娠高血压患者的临床诊断价值。方法随机选取2016年3月—2017年3月该院收治的妊娠高血压患者60例为观察组,选取同时期的健康妊娠晚期孕妇60名为对照组,并将观察组分为轻度子痫前期组(1组)、重度子痫前期组(2组)和子痫组(3组)。比较两组孕妇的血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体水平,并分析观察组不同亚组PT、APTT、TT、FIB和D-二聚体水平。结果观察组患者PT(11.5±0.4)s、TT(14.3±1.9)s、APTT(29.8±3.2)s均比对照组PT(12.4±0.7)s、TT(15.6±2.3)s、APTT(32.4±3.6)s短,观察组FIB(5.7±0.4)g/L和D-二聚体水平(1.2±0.1)mg/L均高于对照组FIB(4.2±0.4)g/L和D-二聚体水平(0.6±0.2)mg/L,差异有统计学意义(P<0.05);比较不同亚组PT、APTT、TT、FIB和D-二聚体水平,差异有统计学意义(P<0.05);3组患者的PT、TT、APTT短于2组和1组,FIB和D-二聚体水平高于2组和1组,差异有统计学意义(P<0.05);2组患者的PT、TT、APTT短于1组,FIB和D-二聚体水平高于1组,差异有统计学意义(P<0.05)。结论检测妊娠期妇女的凝血指标和D-二聚体水平,能有效预防和监测妊娠期高血压疾病的发生和发展,在临床上有十分重要的意义。

Objective This paper tries to investigate the clinical value of coagulation and D-dimer in the diagnosis of pregnancy-induced hypertension. Methods 60 cases of pregnancy-induced hypertension in the hospital in March 2016 to March2017 were selected randomly as observation group, 60 cases of healthy pregnant women in the same period were selected as control group, and the observation group was divided into mild pre-eclampsia group（group One）, severe preeclampsia group（group Two） and eclampsia group（group Three）. PT, TT, APTT, FIB and D-dimer levels were compared between the two groups of subsets PT, APTT, TT, FIB and D-dimer levels. Results In the observation group, PT（11.5±0.4 s）, TT（14.3±1.9）s,and APTT（29.8 ±3.2）s were all higher than those of the control group（12.4 ±0.7）s, TT（15.6 ±2.3）s, and APTT（32.4 ±3.6）s short, the observation group FIB（5.7±0.4）g/L and D-dimer levels（1.2 ±0.1）mg/L were higher than control group FIB（4.2 ±0.4）g/L and D-dimer levels（0.6±0.2）mg/L, the difference was statistically significant（P〈0.05）; the levels of PT, APTT, TT,FIB, and D-dimer in different subgroups were statistically significant（P〈0.05）. The PT, TT and APTT in the three groups were shorter than those in group 2 and group 1. The FIB and D-dimer levels were higher than those in group 2 and group1, and the difference was statistically significant（P〈0.05）; TT and APTT were shorter than group 1, FIB and D-dimer levels were higher than group 1, the difference was statistically significant（P〈0.05）. Conclusion Detection of clotting markers and D-dimer levels in women during pregnancy can effectively prevent and monitor the occurrence and development of hypertensive disorders in pregnancy. It is of great clinical significance.