联合环酯红霉素与阿奇霉素序贯治疗存在支原体血症的小儿支原体肺炎的效果

Effect of erythromycin cyclocarbonate and azithromycin in sequential treatment of children with mycoplasma pneumonia complicated with mycoplasemia

目的分析联合环酯红霉素与阿奇霉素序贯治疗存在支原体血症的小儿支原体肺炎的效果。方法选取2015年1月至2017年1月我院收治的132例存在支原体血症的小儿支原体肺炎患儿,随机将其分为红霉素组、阿奇霉素组及联合序贯组,每组44例。红霉素组单独采用环酯红霉素序贯治疗,阿奇霉素组患儿单独采用阿奇霉素序贯治疗,联合序贯组采用环酯红霉素联合阿奇霉素序贯治疗。观察三组患儿的治疗效果及不良反应发生情况。结果联合序贯组患儿的治疗总有效率均明显优于红霉素组及阿奇霉素组患儿,联合序贯组及阿奇霉素组患儿的不良反应发生率明显低于红霉素组(P<0.05)。结论红霉素与阿奇霉素治疗支原体肺炎均有良好的治疗效果,两种药物各有优点,将红霉素于阿奇霉素进行联合序贯治疗,可综合两者的药物优点,大大提高对支原体肺炎的治疗效果,且不良反应少,值得在临床中广泛应用。

Objective To analyze the effect of erythromycin cyclocarbonate and azithromycin in sequential treatment ofchildren with mycoplasma pneumonia complicated with mycoplasemia. Methods One hundred and thirty -two cases ofchildren with mycoplasma pneumonia complicated with mycoplasemia admitted and treated in our hospital from January2015 to January 2017 were enrolled in this study. All the children were randomly divided into erythromycin group,azithromycin group and sequential combination therapy group, with 44 cases in each group. The children in theerythromycin group were treated with erythromycin cyclocarbonate sequential treatment, children in the azithromycin groupwere treated with azithromycin sequential treatment and the sequential combination therapy group were treated witherythromycin cyclocarbonate and azithromycin sequential treatment. The curative effects and adverse reactions of the threegroups were observed. Results After treatment, the total effective rate of treatment in the sequential combination therapygroup was higher than that in the erythromycin group and the azithromycin group, while the incidence of adverse reactionsin the sequential combination therapy group and the azithromycin group were lower than that in the erythromycin group（P〈0.05）. Conclusion Both erythromycin and azithromycin have good therapeutic effects in the treatment of mycoplasmalpneumonia. Both of them have their own advantages. Combining sequential treatment with erythromycin and azithromycin,the advantages can be combined, significantly improves the curative effect on mycoplasma pneumonia, and with lessadverse reactions, which is worthy of wide application in clinic.