乐脉颗粒治疗脑梗死恢复期的临床观察

Clinical Observation of Lemai Granule on Treating Cerebral Infarction Convalescence

目的观察乐脉颗粒配合常规西药治疗脑梗死恢复期的临床疗效。方法将105例脑梗死恢复期患者随机分为对照组52例与观察组53例,对照组采用西药常规治疗,包括降低血脂、抗凝、营养神经、控制血压和血糖、预防感染等。观察组在对照组治疗基础上加用乐脉颗粒治疗,每日3次,每次2袋,冲服。2组疗程均为1个月。比较2组的临床疗效、血脂[总胆固醇(TC)、三酰甘油(TG)]和血液流变学指标(纤维蛋白原、全血高切黏度、全血低切黏度、血浆黏度、红细胞沉降率)的变化。结果治疗后,对照组总有效率为72.00%,观察组总有效率为90.38%,观察组疗效明显优于对照组(P<0.05);2组TC、TG及血液流变学各项指标均显著降低(P<0.05),观察组改善程度明显优于对照组(P<0.05)。结论乐脉颗粒配合西药治疗能改善脑梗死恢复期患者血脂及血液流变学各项指标,对神经功能的恢复也有较好的促进作用。

Objective To observe the clinical effects of Lemai granule combined with western medicine on treating cerebral infarction convalescence.Methods One hundred and five patients with cerebral infarction convalescence were randomly divided into the observation group（53 cases）and control group（52 cases）.The control group was treated with western medicine,including lowering blood lipid,anticoagulant,neurotrophin,controlling blood pressure and blood sugar,preventing infection,etc.The observation group treated with Lemai granule,3 times a day,2 bags at a time based on the treatment in control group.Both groups were treated for one month.Compared the clinical effects and changes of blood lipid and hemorheology indexes（including the fibrinogen,whole blood viscosity in high shear rate,whole blood viscosity in low shear rate,plasma viscosity and erythrocyte sedimentation rate）in both groups after treatment.Results The total effective rate was 72.00%in the control group and 90.38%in the observation group,which was significantly higher than that in the control group（P〈0.05）.The levels of total cholesterol（TC）,triglyceride（TG）and hemorheology indexes in the two groups were significantly lower than those before treatment（P〈0.05）,but the improvement in the observation group was significantly better than that in the control group（P〈0.05）.Conclusion Lemai granule combined with western medicine can improve the indexes of blood lipid and hemorheology in patients with cerebral infarction in convalescence,and has good effect on the recovery of nervous function of patients.