临床276例次单采血小板输注效果及相关因素分析

Analysis on the Effectiveness and Influencing Factors in 276 Times of Platelet Transfusion

目的分析临床单采血小板输注效果及其影响因素,为科学、合理、有效使用血小板提供参考依据。方法对湖南省胸科医院136例(276例次)输注血小板患者按性别、年龄、血型、输注次数及脾肿大与否分组,进行统计分析,观察患者输注血小板后血小板计数是否有效提高或临床出血症状有否改善,评价血小板输注效果。结果 276例次输注单采血小板中有效194例次,有效率为70.29%,性别、年龄及血型对输注效率无影响(P>0.05),不同输注次数总体组间差异有统计学意义(P<0.05),同时脾肿大患者较脾正常患者疗效差异有统计学意义(P<0.01)。结论血小板输注次数和脾脏肿大是影响输注效果的因素,临床医生应该严格控制患者输注血小板指征、掌握患者情况并在输注时避免各种诱发因素,减少或避免无效输注的发生,提高血小板输注有效率及临床疗效。

Objective To provide evidence for effective use of platelet through analyzing the efficiency ofplatelets transfusion and its influencing factors. Methods Statistical analysis was carried out for 276 times of platelet transfusion in 186 patients based on gender, age, blood groups, transfusion frequency, and splenomegaly. Peripheral blood PLT count and clinical symptoms of hemorrhage were evaluated for platelet transfusion efficiency. Results One hundred and ninety- four transfusions were found to be effective in 276 transfusions （70.29%） . Both sex and age showed no significant impact on platelet transfusion efficiency （P〉0.05） . The frequency ofplatelet transfusion negatively correlated with transfusion efficiency （P〈0.05） . The patients with splenomegaly presented a significant impact on platelet transfusion efficiency （P〈0.01） . Conclusions The transfusion frequency and splenomegaly are influencing factors of the transfusion efficiency. Attention should be paid to the indications of the patients in PLT transfusion so as to reduce or avoid the occurrence of invalid transfusion and improve the efficiency of PLT transfusion and clinical efficacy.