小牛血清去蛋白注射液联合高压氧对急性脑梗死患者神经功能的影响

The Therapeutic Effect of Deproteinized Calf Serum Injection Combined with Hyperbaric Oxygen on Neurological Function and Serum VEGF,MMP-9 and BDNF in Patients with Acute Cerebral Infarction

目的探讨小牛血清去蛋白注射液联合高压氧对急性脑梗死患者神经功能及血清血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP-9)、碱性成纤维细胞生长因子(BDNF)水平变化的影响。方法选取2015年1月～2017年4月本院急性脑梗死患者92例,根据随机数表法分为2组,每组46例。对照组予以小牛血清去蛋白注射液治疗,实验组予以小牛血清去蛋白注射液+高压氧治疗。疗程结束后,观察记录两组治疗效果、不良反应情况,并对比两组治疗前后神经功能评分、血清VEGF、MMP-9、BDNF水平及生活质量变化情况。结果实验组治疗总有效率93.48%(43/46)高于对照组78.26%(36/46),差异有统计学意义(P<0.05);相比对照组,治疗后实验组NIHSS评分较低,生理功能、精力、精神状态、健康状况评分均较高,差异有统计学意义(P<0.05);相比对照组,治疗后实验组血清VEGF、BDNF水平较高,MMP-9水平较低,差异有统计学意义(P<0.05);实验组不良反应率19.57%(9/46)与对照组15.22%(7/46)相比,差异无统计学意义(P>0.05)。结论联合采用小牛血清去蛋白注射液、高压氧治疗急性脑梗死,可明显降低血清MMP-9水平,有效提高VEGF、BDNF水平,显著改善患者神经功能及生活质量,进一步提高治疗效果,且安全性较高。

Objective To investigate the effect of deproteinized calf serum injection （DCSI） combined with hyperbaric oxygen on neurological function and serum levels of vascular endothelial growth factor （VEGF）,matrix metalloproteinases （MMP-9） and basic fibroblast growth factor （BDNF） in patients with acute cerebral infarction （ACI）. Methods Ninety two patients with ACI in the hospital were selected in the last two years and divided into 2 groups,46 cases in each. The control group was given DCSI only whereas the experimental group was treated with both DCSI and hyperbaric oxygen. The treatment efficacy and adverse reactions were recorded. The neurological function score,serum levels of VEGF,MMP-9,BDNF and quality of life were compared between the two groups pre- and post-treatment. Results The total effective rate of the experimental group was 93.48% （43/46）,which was higher than that of the control group （78.26%,36/46）（P 〈0.05）. The scores of NIHSS in the experimental group were lower while physiological function, energy,mental state and health status were higher than those in the control（P 〈0 .0 5）. The levels of serum VEGF and BDNF in the experimental group were elevated whereas MMP-9 was decreased（P 〈0.05）. No significant difference of the adverse reactions was seen between in the experimental （19.57%,9/46） and control groups （15.22%,7/46）（P 〉0.05）. Conclusion Deproteinized calf serum injection combined with hyperbaric oxygen in the treatment of acute cerebral infarction can obviously decrease the levels of MMP-9 and VEGF,effectively elevate the level of BDNF,and improve the neurological functions and the quality of life of patients with acute cerebral infarction.