进展性卒中病因及相关因素分析

Analysis of pathogeny and related factors of progressive stroke

目的分析进展性卒中病因及相关因素。方法 100例接受治疗的脑卒中患者,根据病情分成进展性卒中组(30例)和非进展性卒中组(70例)。回顾性分析两组患者临床资料,比较两组患者的基线资料和检查结果。结果进展性卒中组高血压病史、吸烟史、糖尿病史占比,以及糖化血红蛋白、空腹血糖、低密度脂蛋白胆固醇(LDL-C)水平与非进展性卒中组比较,差异具有统计学意义(P<0.05);进展性卒中组病情进展峰值时美国国立卫生研究院卒中量表(NIHSS)评分显著高于本组入院时及同期非进展性卒中组,差异具有统计学意义(P<0.05);进展性卒中组入院3 d内血压下降幅度≥20%比例为50.00%显著高于对照组的28.75%,差异具有统计学意义(P<0.05)。结论血压、吸烟史、糖尿病史、糖化血红蛋白、空腹血糖、低密度脂蛋白胆固醇等数据均具有重要的临床价值,在脑卒中患者入院治疗时开始掌握这些信息为参考,对制定更有效的治疗方案以及避免患者发生进展具有重要的临床意义。

Objective To analyze the pathogeny and related factors of progressive stroke. Methods A total of 100 stroke patients were divided by patient＇s conditions into progressive stroke group（30 cases） and non-progressive stroke group（70 cases）. The clinical data of the two groups were collected for retrospective analysis and comparison. The general data and test results of the two groups were compared. Results Progressive stroke group had statistically significant difference in hypertension history, smoking history, diabetes history, glycosylated hemoglobin, fasting blood glucose, low density lipoprotein cholesterol（LDL-C）, comparing with nonprogressive stroke group（P〈0.05）. The peak National Institute of Health stroke scale（NIHSS） score in progressive stroke group was significantly higher than admitted to hospital and that in non-progressive stroke group, and their difference was statistically significant（P〈0.05）. Progressive stroke group had obviously higher proportion of blood pressure decreased by more than 20% within 3 d after admission as 50.00% than 28.75% in non-progressive stroke group, and the difference was statistically significant（P〈0.05）. Conclusion Blood pressure, smoking history, diabetes history, glycosylated hemoglobin, fasting blood glucose, low density lipoprotein cholesterol are of great clinical value. It is of important clinical significance for the stroke patients to begin to master these information as a reference, so as to make more effective treatment regimens and avoid the progress of the disease.