肝肾综合征临床诊断标准的变迁及新的肾损伤指标在肝硬化患者中的应用

Changes in diagnostic criteria for hepatorenal syndrome and the application of new renal injury indices in cirrhotic patients

肝肾综合征是一种严重的失代偿期肝硬化并发症,短期病死率极高。目前尚缺乏有效的内科治疗方法,一些药物尽管有效,但其报道的疗效不一,原因之一是诊断标准并不统一。介绍了肝肾综合征诊断标准的变迁和新的肾损伤指标或方法,指出一个统一的诊断标准将成为肝肾综合征临床研究的基础,也有利于临床医生进一步认识此严重的肝硬化并发症。

Hepatorenal syndrome is a serious complication of decompensated cirrhosis and has high short-term mortality. There still lacks effective medical treatment at present. Although some drugs are effective,but their effects reported in the literature were different due to a lack of uniform diagnostic criteria. This article introduces the changes in the diagnostic criteria for hepatorenal syndrome and points out that uniform diagnostic criteria will become the basis for clinical research on hepatorenal syndrome and may also help clinicians to understand this serious complication of liver cirrhosis.