摘要
Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries(IRIs) after surgery.Methods Forty male Sprague-Dawley rats were randomly divided into a sham operation group(S group), ischemia reperfusion group(IR group), probucol low-dose treatment group(probucol + IR group 1, P+ IR1 group; probucol 250 mg/kg intragastric administration daily), and probucol high-dose treatment group(P + IR2 group; probucol 500 mg/kg intragastric administration daily). Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase(SOD), and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.Results Twenty-four-hour urinary protein excretion, urinary NAGase, Cys C, blood urea nitrogen(BUN), and creatinine were significantly lower in the P + IR1 and P + IR2 groups than in the IR group(P < 0.05). Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly(P < 0.05), renal pathological injury was alleviated, and the kidney index improved significantly(P < 0.05).Conclusion Probucol can relieve various types of acute renal failure in postoperative rats.
Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries（IRIs） after surgery.Methods Forty male Sprague-Dawley rats were randomly divided into a sham operation group（S group）, ischemia reperfusion group（IR group）, probucol low-dose treatment group（probucol ＋ IR group 1, P＋ IR1 group; probucol 250 mg/kg intragastric administration daily）, and probucol high-dose treatment group（P ＋ IR2 group; probucol 500 mg/kg intragastric administration daily）. Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase（SOD）, and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.Results Twenty-four-hour urinary protein excretion, urinary NAGase, Cys C, blood urea nitrogen（BUN）, and creatinine were significantly lower in the P ＋ IR1 and P ＋ IR2 groups than in the IR group（P 〈 0.05）. Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly（P 〈 0.05）, renal pathological injury was alleviated, and the kidney index improved significantly（P 〈 0.05）.Conclusion Probucol can relieve various types of acute renal failure in postoperative rats.
基金
Supported by Scientific Research Project of Hubei Provincial Health and Family Planning Commission(No.WJ2015Z042)
