神经节苷脂联合家庭康复训练对HIE患儿神经损伤、神经发育及氧化应激的影响

Effects of gangliosides combined with family rehabilitation training on nerve injury,neurodevelopment and oxidative stress in children with HIE

目的:研究神经节苷脂联合家庭康复训练对HIE患儿神经损伤、神经发育及氧化应激的影响。方法:选择2015年3月~2017年10月期间自贡市第三人民医院收治的HIE患儿并随机分为两组,康复训练组接受神经节苷脂联合家庭康复训练、阴性对照组接受神经节苷脂联合常规康复干预。干预前及干预后3个月时,测定血清中神经损伤分子、神经营养分子、氧化应激分子的含量。结果:与组内干预前比较,两组患儿干预后3个月时血清中VILIP1、NSE、UCH-L1、TNF-α、IL-6、NO、DM、MDA的含量均显著降低,BDNF、TRKB、NTF、NGF、SOD、GSH-PX的含量均显著升高且康复训练组患儿干预后血清中VILIP1、NSE、UCH-L1、TNF-α、IL-6、NO、DM、MDA的含量低于阴性对照组,BDNF、TRKB、NTF、NGF、SOD、GSH-PX的含量高于阴性对照组。结论:神经节苷脂联合家庭康复训练能用于HIE患儿够减轻神经损伤、改善神经发育、抑制氧化应激。

Objective：To study the effects of gangliosides combined with family rehabilitation training on nerve injury,neurodevelopment and oxidative stress in children with HIE.Methods：Children with HIE who were treated in Zigong Third People＇s Hospital between March 2015 and October 2017 were selected and randomly divided into two groups,rehabilitation training group received gangliosides combined with family rehabilitation training and negative control group accepted gangliosides combined with conventional rehabilitation intervention.The contents of nerve injury molecules,neurotrophic molecules and oxidative stress molecules in serum were measured before intervention and 3 months after intervention.Results：Compared with those of same group before intervention,serum VILIP1,NSE,UCH-L1,TNF-α,IL-6,NO,DM and MDA levels of both groups of children were significantly lower whereas BDNF,TRKB,NTF,NGF,SOD and GSH-PX levels were significantly higher 3 months after intervention,and serum VILIP1,NSE,UCH-L1,TNF-α,IL-6,NO,DM and MDA levels of rehabilitation training group after intervention were lower than those of negative control group whereas BDNF,TRKB,NTF,NGF,SOD and GSH-PX levels were higher than those of negative control group.Conclusion：Gangliosides combined with family rehabilitation training can reduce the nerve injury,improve the neurodevelopment and inhibit the oxidative stress in children with HIE.