氯沙坦对原发性高血压患者尿蛋白排泄的影响

Effect of Losartan on the Excretion of Urine Protein in Essential Hypertension

目的 :探讨氯沙坦对原发性高血压肾功能损害的影响。方法 :选择 54例EH患者和NC组 30例 ,氯沙坦 50mg ,每天 1次 ,治疗 4周 ,比较EH与NC组及EH组用药前后肾功能和尿蛋白的改变。结果 :EH组 2 4hUTP、2 4hUAlb明显高于NC组 ,EH组氯沙坦治疗 4周后2 4hUTP、2 4hUAlb、2 4hα1 MG、2 4hβ2 MG排泄率明显低于治疗前。结论 :氯沙坦对EH患者有良好的早期保护肾功能作用。

Objective:To discuss the effect of losartan on impairment of renal function in essential hypertension(EH). Methods: 54 EH patients and 30 normal controls were studied. After 4 weeks treatments by losartan 50mg per day, the changes of renal function and urine protein were compared between EH group and NC group,and the pre and post treatment changes in EH group. Results: Before treatment, 24h UTP, 24h UAlb in EH is obviously higher than those in NC(P<0.05). In EH group, the excretion of 24h UTP,24h UAlb,24h Uα 1MG,24h Uβ 2MG decreased significantly after 4 weeks treatment with losartan(P<0.05). Conclusion:Losartan has satisfactory effect on earlier protection of renal function in EH patients.