2013-2015年山东某院呼吸道感染患者9种病原体血清IgM抗体检测情况

Analysis of detection of nine pathogens serum IgM antibody in patient with respiratory tract infection in a hospital of Shandong province from 2013 to 2015

目的通过分析该院2013年1月至2015年12月共4 115例呼吸道感染患者病原体IgM抗体检测情况,了解该地区呼吸道感染病原体流行病学情况。方法采用间接免疫荧光法分别检测4 115例呼吸道感染患者血清中嗜肺军团菌(LP)、肺炎支原体(MP)、Q热立克次体(COX)、肺炎衣原体(CP)、呼吸道合胞病毒(RSV)、腺病毒(ADV)、甲型流感病毒(IFA)、乙型流感病毒(IFB)、副流感病毒(PIVS)9项病原体IgM抗体,分析各种病原体的感染率及不同季节的感染情况。结果 4 115例患者血清中单项病原体检出率为24.86%,其中IFB为21.70%,MP为21.30%,PIVS为21.11%,LP为13.10%,ADV为9.29%,IFA为6.26%,RSV为5.67%,COX为0.98%,CP为0.59%,2项病原体混合感染检出率为3.30%,3项病原体联合检出率为2.48%,4项病原体联合检出率为0.19%。IFB、MP、PIVS和LP在不同季节检出率也有差异。结论该院呼吸道感染病原体以IFB、MP、PIVS和LP感染为主。LP、MP、IFB、PIVS在春季检出率明显高于其他季节,应针对不同的病原体和不同的季节应及早预防,做到早发现、早诊断、早治疗。

Objective To analyze the detection of pathogens IgM antibody in 4 115 patients with respiratory tract infections in Shandong Provincial Hospital from January 2013 to December 2015,and the epidemiological characteristics of respiratory tract infections were analyzed in this area. Methods Legionella pneumophila （LP）,mycoplasma pneumoniae （MP）,coxiella burnetii （COX） and chlamydia pneumoniae （CP）,respiratory syncytial virus （RSV）,adenovirus （ADV）,influenza A virus （IFA）,influenza B virus （IFB）,parainfluenza virus （PIVS） in 4 115 respiratory tract infection patients were detected by indirect immunofluorescence method. Results In 4 115 cases,the detection rate of single pathogen was 24.86%,the rate of IFB was 21.70%,the rate of MP was 21.30%,the rate of PIVS was 21.11%,the rate of LP was 13.10%,the rate of ADV was 9.29 %,the rate of IFA was 6.26%,the rate of RSV was 5.67%,the rate of COX was 0.98%,the rate of CP was 0.59%,the detection rate of two mixed infection pathogen was 3.30%,the detection rate of three joint pathogen was 2.48%,the detection rate of four joint pathogen was 0.19%.The detection rates of IFB,MP,PIVS,LP were different in different season. Conclusion The main pathogen of respiratory tract infection in this area are IFB,MP,PIVS and LP.The detection rates of LP,MP,IFB,PIVS are significantly higher in spring than other seasons,it should be early prevented,detected,diagnosed,treated according to different pathogens and different season.