钙通道阻滞剂联合阿片类治疗老年神经病理性癌痛的临床研究

Clinical study of calcium channel blocker combined with opioid in the treatment of elderly patients with neuropathic pain

目的:观察钙通道阻滞剂联合阿片治疗老年神经病理性癌痛及其对相关血清指标的影响,为临床诊治提供借鉴。方法:选取我院于2015年11月至2017年11月收治的96例老年神经病理性癌痛患者为研究对象,以住院号单双随机分成2组,其中对照组48例仅采用吗啡治疗(阿片类),试验48例在对照组的基础上加用普瑞巴林(钙通道阻滞剂)。对比两组治疗前后疼痛积分改善情况,血清指标及临床疗效。结果:治疗后试验组治愈率29.17%、总有效率91.67%,对照组治愈率14.58%、总有效率72.92%,试验组优于对照组(P<0.05);两组治疗后疼痛积分均优于治疗前,血清指标p物质、β-内啡肽、5-羟色胺均改善明显,且试验组各疼痛积分及血清学指标均优于对照组(P<0.05)。结论:与单用吗啡治疗对比,联合普瑞巴林可有效治疗重度癌痛,改善患者疼痛,促进其血清学指标恢复正常。

Objective：To study the effect of calcium channel blocker combined with opioid in the treatment of senile neuropathic cancer pain and its influence on related serum indexes,and to provide reference for clinical diagnosis and treatment.Methods：96 cancer patients were selected from our hospital in November 2015 to 2017 November as the research object,in hospital number of single and double random divided into 2 groups,including 48 cases in the control group only used morphine treatment （opioids）,experimental group 48 cases in the control group based on the use of puri balin （calcium channel blocker）.Compared two groups before and after treatment pain score improvement,serum indicators and clinical efficacy.Results：The pain scores were better than the treatment of the two groups after treatment,serum substance p,beta endorphin,5- serotonin were improved obviously,and the experimental group pain score and serum indexes were better than the control group （P＜0.05）,the experimental group cure rate was 29.17%,the total effective rate was 91.67%,the cure rate of the control group,14.58% the total efficiency of 72.92%,the experimental group than the control group （P＜0.05）.Conclusion：with morphine treatment contrast,combined with pregabalin can be effective in the treatment of severe pain,improve the patients pain scores,promote their serological indexes returned to normal,is conducive to the treatment effect.