新肿瘤治疗模式:化疗联合免疫治疗

Chemotherapy and immune therapy combinations for the next chemotherapeutic practice

化疗不仅限于细胞毒性作用,也能激活抗肿瘤免疫反应。化疗通过释放肿瘤细胞抗原、调节T细胞功能、重构免疫微环境和减少免疫抑制细胞等机制激活免疫反应,临床研究支持化疗联合免疫治疗可以提高抗肿瘤效果。系统化疗和免疫治疗的联合可能成为二代肿瘤化疗的标准模式。本文对化疗联合免疫治疗的作用机制、临床研究和模式作一综述。

The efficacy of chemotherapy does not involve direct cytotoxic effects,but also relies on the activation of tumor-targeting immune responses.Rational combinations of chemotherapy with immunotherapy could provide the standard of care for the next chemotherapeutic practice.In this review,we explore the mechanisms,clinical study and models for this synergism.