Lnc-miRNA轴在子宫内膜癌中的研究进展

Research progress on lnc-miRNA axis in endometrial cancer

子宫内膜癌是一种女性常见的上皮性恶性肿瘤,临床上多表现为绝经后阴道出血,其中子宫内膜样腺癌是最常见的组织亚型。统计发现子宫内膜癌的发病率逐年升高,现已成为发达国家女性最常见的生殖道恶性肿瘤。研究报道,无转移患者5年总生存率为74%~91%。早期预防、诊断及有效治疗成为了减少手术创伤,提高术后生存质量,保留患者生育功能,延长生存时间的有效方法。目前越来越多的报道指出,一些lncRNA在子宫内膜癌组织和细胞中表达失衡,不仅推动了子宫内膜癌发生、发展机制的研究,也为临床上内膜癌的治疗提供了新的理论基础。但其调控miRNA的机制和对子宫内膜癌细胞恶性生物学行为的影响仍有待进一步研究。随着对lnc-miRNA轴研究的不断深入,lncRNA和miRNA将有望成为新的子宫内膜癌诊断和预后标志物。

Endometrial cancer is a common gynecologic epithelial malignancy,mainly characterized by the symptom of postmenopausal bleeding.Through a review of the literature it was found that the clinical subtype of endometrial cancer is primarily endometrioid.As the number of patients with endometrial cancer is likely to continue to grow,it has become the most common malignancy of the female genital tract in developed countries.Evidence shows that the overall 5-year survival rate of non-metastasis patients is 74%~91%.Besides,early prevention,timely diagnosis and effective treatment are known to be highly effective for reducing surgical trauma,improving postoperative life quality,retaining fertility function and prolonging survival time.Recently,a growing body of studies report aberrant expression of some lncRNAs in endometrial tissues and cell lines,the study on which facilitates the understanding on mechanisms of formation and development of endometrial carcinoma,and provides a new evidence for clinical treatment.Nevertheless,its mechanisms of miRNA expression regulation and its effects on malignant biological behaviors of endometrial cancer cells are still controversial.With the deeper understanding of lnc-miRNA axis,lncRNA and miRNA may prove to be valuable biomarkers for diagnosis and therapy of endometrial carcinoma.