阿尔兹海默病患者血浆中三种抗氧化维生素水平的Meta分析

Meta-analysis of vitamin C,vitamin E and β-carotene levels in the plasma of Alzheimer's disease patients

目的系统评价阿尔兹海默病(Alzheimer's disease,AD)患者血浆中维生素C、维生素E和β-胡萝卜素的水平。方法计算机检索Pubmed、Science Direct、中国知网和万方数据库中发表的关于AD患者血浆中维生素C、维生素E和β-胡萝卜素水平的病例-对照研究和横断面研究(非膳食外补充),检索时限均为建库到2017年7月。结果 Meta分析结果显示,与对照组相比,AD患者血浆中维生素E的水平显著下降(SMD=-1.49μmol/L,95%CI-2.08^-0.89μmol/L,P<0.001)。维生素C和β-胡萝卜素,病例组和对照组差异无统计学意义(维生素C:SMD=-1.43μmol/L,95%CI-3.05~0.19μmol/L,P=0.083;β-胡萝卜素:SMD=-0.61μmol/L,95%CI-1.40~0.18μmol/L,P=0.131)。结论通过增加膳食中维生素E含量丰富的食物来提高血浆中维生素E的水平是AD的保护性因素,但尚不能认为维生素C和β-胡萝卜素对AD的发生有明显的影响。

Objective To systematically evaluate the levels of vitamin C,vitamin E and β-carotene in the plasma of Alzheimer’s disease（ AD） patients.Methods In this study,literature of the levels of vitamin C,vitamin E and β-carotene in the plasma of AD patients were collected by retrieving the database of Pub Med,Science Direct,CNKI and Wan Fang（ from they were built to July 2017）.Results Meta-analysis result showed that,compared with the control group,the level of vitamin E in the plasma of AD patients declined significantly（ SMD =-1.49 μmol/L,95% CI-2.08--0.89 μmol/L,P 〈0.001）.However,no differences were determined in the levels of the plasma vitamin C and β-carotene between the two groups（ vitamin C： SMD =-1.43 μmol/L,95% CI-3.05-0.19 μmol/L,P = 0.083; β-carotene： SMD =-0.61 μmol/L,95% CI-1.40-0.18 μmol/L,P = 0.131）.Conclusion Increasing vitamin E level in the plasma through vitamin E riched diet may be useful to prevent AD.However it is not yet believed the benefical role on AD to increase vitamin C and β-carotene.