支原体感染与不孕及不良妊娠结局的相关性分析

Correlation analysis between mycoplasma infection and infertility adverse pregnancy outcomes

目的探讨支原体感染与不孕症和不良妊娠结局的相关性。方法选择2016年1-12月医院收治的不孕症或不良妊娠治疗的患者120例,依据患病的种类,将其分为不孕不育组(试验A组)40例、不良妊娠结局组(试验B组)40例及正常妊娠组(对照组)40例。试验过程中,观察三组患者支原体感染情况,统计试验B组中各种不良妊娠结局患者支原体感染情况,同时比较试验B组支原体阴性、阳性中不良妊娠结局分布情况,针对所有患者行精细化护理。结果试验A组患者支原体感染阳性25例,感染率为62.50%;试验B组患者支原体感染阳性12例,感染率为30.00%;对照组患者支原体感染阳性5例,感染率为12.50%,三组差异有统计学意义(P<0.05)。试验组患者单独解脲支原体(U.urealyticum,UU)感染敏感率较高的为米罗沙星(96.00%)、多西环素(96.00%)、交沙霉素(96.00%);阿洛西林(96.00%);、克拉维酸等(96.00%);单独人支原体(M.hominis,MH)感染敏感率较高的为多西环素(100.00%)、交沙霉素(100.00%)、克林霉素(100.00%);UU和MH混合感染药物敏感率较高米罗沙星(100.00%)、多西环素(100.00%)。试验B组中各种不良妊娠结局患者支原体感染情况:流产患者17例,支原体感染阳性5例,感染率29.41%;胎膜早破患者14例,支原体感染阳性4例,感染率高达28.57%;早产患者9例,支原体感染阳性3例,感染率高达33.33%。结论支原体感染状态与不孕症和不良妊娠结局之间密切相关,临床实践中应更多关注适龄女性支原体感染情况。

OBJECTIVE To investigate the relationship between mycoplasma infection status and infertility and adverse pregnancy outcomes.METHODS A total of 120 patients with infertility or adverse outcome pregnancy were selected from Jan.2016 to Dec.2016,and were divided into the experimental A group which had 40 infertile patients,the experimental B group which had 40 adverse pregnancy outcome patients,and the control group which had 40 normal pregnancy patients.During the course of the trial,the infection status of mycoplasma in three groups was observed.The infection of mycoplasma in all the adverse pregnancy outcomes in experimental B group was statistically analyzed,and at the same time the adverse pregnancy outcome distribution in mycoplasma negative and positive patients of experimental B group were compared.Meticulous nursing was performed for all patients.RESULTS In experimental A group,25 cases had positive mycoplasma infection,with the infection rate of62.3%.In experimental B group,12 cases had with positive mycoplasma infection,with the infection rate of30.0%.In control group,there were 5 cases of positive mycoplasma infection and the infection rate was 12.5%.The difference between the three groups was significan（P〈0.05）.Muroxin（96%）,doxycycline（96%）,josamycin（96%）,azlocillin（96%）,and clavulanic acid（96%）were the most sensitive to U.urealyticum（UU）infection in the experimental group.M.hominis（MH）infection was sensitive to doxycycline（100%）,josamycin（100%）,and clindamycin（100%）.UU and MH coinfection was highly sensitive to mirofloxacin（100%）and doxycycline（100%）.Patients with various adverse pregnancy outcomes in experimental B group were infected with mycoplasma：17 patients were miscarriage,and 5 were positive for mycoplasma infection,with the infection rate of 29.41%,14 were premature rupture of membranes,and 4 were positive for mycoplasma infection,with the infection rate of 28.57%,and 9 cases of premature birth,and 3 cases were positive for mycoplasma infection,with the infection rate as high as 33.33%.CONCLUSION The infection status of mycoplasma infection is closely related to infertility and adverse pregnancy outcomes.More attention should be paid to the situation of female mycoplasma infection in clinical practice.