摘要
EF-P(Elongation factor P)是普遍存在于细菌中的蛋白质翻译延伸因子,因其L型结构与t RNA类似,可挽救聚脯氨酸导致的翻译延宕,减缓核糖体的失速效应。EF-P虽然不是细菌生存的必需蛋白,但是对细菌自身的环境适应性以及一些致病菌的毒性维持至关重要。本文综述了细菌EF-P的结构、功能及其相关研究进展。
EF-P（Elongation factor P） is a translation elongation factor commonly conserved in bacteria. Due to its L-shaped structure similar to t RNA, EF-P can rescue stalled ribosome caused by polyproline. Although it is not an essential protein in bacteria, it is crucial for bacterial fitness and virulence of some pathogens. In this paper, the structure, function and related research progress of bacterial EF-P are reviewed.
作者
赖爱兰
黄运红
龙中儿
LAI Ai-Lan;HUANG Yun-Hong;LONG Zhong-Er(College of Life Sciences,Jiangxi Normal University,Nanchang,Jiangxi 330022,Chin)
出处
《微生物学通报》
CAS
CSCD
北大核心
2018年第7期1555-1562,共8页
Microbiology China
基金
国家自然科学基金(31360018)~~
关键词
EF-P
核糖体
聚脯氨酸
翻译
Elongation factor P
Ribosome
Polyproline
Translation
