40例COPD合并呼吸衰竭发生肺部真菌感染的危险因素分析

Risk factors of pulmonary fungal infection in 40 cases of patients with COPD complicated with respiratory failure

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并呼吸衰竭发生肺部真菌感染的危险因素。方法:收集40例COPD合并呼吸衰竭发生肺部真菌感染的患者相关资料,采用SPSS数据处理后,利用logistic回归分析COPD合并呼吸衰竭发生肺部真菌感染的危险因素。结果:单因素logistic回归分析提示年龄、病程、吸烟、机械通气、呼吸衰竭、低蛋白血症是患者出现肺部真菌感染的危险因素(P<0.05);多因素logistic回归分析提示病程、呼吸衰竭、低蛋白血症均是患者出现肺部真菌感染的危险因素(P<0.05)。结论:患者的病程越长、出现低蛋白血症、出现呼吸衰竭现象都是肺部真菌感染发生的独立危险因素,临床上应当对这些危险因素进行及早的预防或治疗干预。

Objective： To explore the risk factors of pulmonary fungal infection in patients with COPD complicated with respiratory failure. Methods： The clinical data from 40 COPD cases complicated with respiratory failure and pulmonary fungal infection were selected and their risk factors were analyzed by logistic regression analysis. Results： The risk factors of pulmonary fungal infection were associated with age, course, smoking, mechanical ventilation, respiratory failure and hypoproteinemia by univariate logistic regression analysis and with course, respiratory failure and hypoproteinemia by multivariate logistic regression analysis（P〈0.05）. Conclusion： The longer course and the occurrence of hypoproteinemia and respiratory failure are the independent risk factors for pulmonary fungal infections, which should be clinically intervened by early prevention or early treatment.