非小细胞肺癌靶向治疗研究的分析

Analysis of the targeted therapy of non-small cell lung cancer

目的用文献计量学方法探索非小细胞肺癌(NSCLC)靶向治疗的研究概况和发展趋势。方法在Web of Science数据库中检索1986年至2017年有关NSCLC靶向治疗的文献,分析其年发文量、国家/地区、机构、作者、来源出版物和被引情况。结果共检索得655篇文献,数量有限但是增长迅速。美国的发文量占全球的34%,并有4个机构发文量排进前10;我国发文量占全球的20%,并有4个机构发文量排进前10。全球以美国德州大学MD安德森癌症中心发表文章最多,国内以山东大学发文最多。结论 NSCLC的靶向治疗是全球新兴的研究热点之一,美国在该研究领域具有领先地位,我国发文量较大但仍与国际前沿研究存在一定差距。

Objective To investigate the research status and development trends of the targeted therapy of non-small cell lung cancer（ NSCLC） using bibliometric analysis. Methods The literatures on targeted therapy of NSCLC were retrieved from 1986 to 2017 in Web of Science database,and their published years,countries/regions,institutions,authors,journal distribution and cited situation were analyzed.Results A total of 655 literatures concerning targeted therapy of NSCLC were obtained. The number of global published articles is low but growing progressively,34% of which were from USA and 20% of which were from China. In the top 10 institutions,4 institutions were from USA and 4 institutions were from China. The University of Texas MD Anderson Cancer Center from USA issued the largest number of publications in this field globally,and in China,the Shandong University took the first place. Conclusion At present,the targeted therapy of NSCLC is novel and attracting more and more attentions. USA leads the world in this field which followed by China,but there is still a certain gap between them.