局部晚期结肠癌术前化疗的研究进展

Advance in preoperative chemotherapy for locally advanced colon cancer

局部晚期结肠癌患者手术后复发率高,预后较差,亟待提高患者的生存质量。研究表明,更早的全身治疗可有效根除肿瘤微转移,降低肿瘤复发和转移风险。术前化疗作为全身治疗的一种,在胃癌、乳腺癌及食管癌的治疗中被证明有效,但术前化疗在局部晚期结肠癌中的疗效尚不明确。为探索术前化疗在局部晚期结肠癌中的可行性及有效性,探讨局部晚期结肠癌的治疗策略,本综述重点探讨局部晚期结肠癌患者实施术前化疗的理论基础及临床疗效、CT作为一种有效手段用于筛选符合术前化疗标准的患者并评价术前化疗的疗效,以及结肠癌术前化疗未来研究的方向。

The patients with locally advanced colon cancer have high recurrence rate and poor prognosis after operation, so their quality of life needs to be improved. The present studies show that the early systemic treatment is able to eradicate tumor micrometastasis effectively and reduce the risks of tumor recurrence and metastasis. Preoperative chemotherapy as a kind of systemic treatment is effective for gastric cancer, breast cancer and esophageal cancer, but its curative effect on locally advanced colon cancer is not clear. To explore the feasibility and effectiveness of preoperative chemotherapy for the locally advanced colon cancer and to discuss the treatment strategy of locally advanced colon cancer, this review focuses on the theoretical basis and the clinical efficacy of preoperative chemotherapy for the patients with locally advanced colon cancer, and CT as a mean of screening the patients with preoperative chemotherapy standards and evaluating the curative effect of preoperative chemotherapy, as well as the future research directions of preoperative chemotherapy for colon cancer.