养肝益水颗粒治疗高血压合并睡眠障碍的临床研究

Clinical Observation on Yanggan Yishui Granule in the Treatment of Hypertension Complicated with Sleep Disturbance

目的观察养肝益水颗粒治疗高血压合并睡眠障碍的临床疗效。方法将66例高血压合并睡眠障碍病人随机分为治疗组与对照组,各33例。两组均给予基础降压治疗,治疗组口服养肝益水颗粒,对照组口服谷维素。治疗6周后,比较两组临床疗效,观察两组治疗前后清晨血压、匹兹堡睡眠质量指数量表(PSQI)评分、血清同型半胱氨酸(Hcy)和胱抑素C(Cys C)变化。结果治疗后治疗组临床总有效率为68.75%,明显高于对照组的40.00%,两组比较差异有统计学意义(P<0.05)。治疗后治疗组血压、Hcy和Cys C含量明显低于对照组,差异有统计学意义(P<0.05或P<0.01);PSQI入睡时间和总分明显低于对照组,差异有统计学意义(P<0.01)。结论养肝益水颗粒能有效改善高血压病人睡眠状况,提高睡眠质量,有效控制血压,降低血清Hcy和Cys C水平。

Objective To observe the effect of Yanggan Yishui granule（YYG）in the treatment of hypertension complicated with sleep disorders.Methods Sixty-six hypertensive patients with sleep disturbance were randomly divided into two groups：control group（n =33）treated with oryzanol orally,and treatment group（n =33）treated with YYG in the basis of routine antihypertension for 6 weeks.The clinical efficacy of sleep disturbance,hypertension,the Pittsburgh Sleep Quality Index（PSQI）score,as well as the content of serum homocysteine（Hcy）and cystain C（Cys C）were observed and compared before and after the treatment.Results The total effective rate in the treatment group after treatment was 68.75%,which was significantly higher than that in the control group（40.00%,P〈0.05）.After treatment,the blood pressure,Hcy and Cys C levels in the treatment group were significantly lower than those in the control group（P〈0.05 or P〈0.01）.The PSQI sleep time and total score in the treatment group were significantly lower than the control group（P〈0.01）.Conclusion YYG can effectively improve the sleep condition and sleep quality,effectively control blood pressure,and reduce serum Hcy and Cys C levels in patients with hypertension complicated with sleep disturbance.