L-阿拉伯糖解酒功能及机制

Sobering Effect of L-Arabinose & Its Operating Mechanism

考察L-阿拉伯糖对小鼠醉酒模型的解酒作用和机制,L-阿拉伯糖对饮酒后小鼠的肝脏中乙醛含量的变化的影响等生物功能学作用,为其在缓解酒精对肝脏和肠胃的损伤,以及在食品中的应用提供理论依据。按照15 m L/kg体重以56%vol红星二锅头酒一次性灌喂法建立小鼠醉酒模型,采用L-阿拉伯糖低、中、中高、高4种剂量进行酒前、同时、酒后3种方式灌喂干预,以翻正反应消失时间、翻正反应消失持续时间和醉酒率、醒酒率作为考察指标。结果表明,与模型组比较,口服中剂量以上的L-阿拉伯糖可显著减少小鼠醉酒率和醒酒率。此外,通过检测乙醛脱氢酶在肝脏中的浓度变化,发现服用L-阿拉伯糖能够促进乙醛脱氢酶的分泌。L-阿拉伯糖具有显著的解酒醒酒的功能,尤其酒前服用能够有效改善酒精中毒的症状。

To study the sobering effect of L-arabinose on drunk mice, and to explore the optimal amount of daily L-arabinose intake for sobering and its influence on acetaldehyde dehydrogenase（ALDH） level of mice liver, adult mice were randomly selected and assigned into five groups. One-time liquor intragastric administration of all mice was performed according to the amount of 15 m L/kg（56 %vol Hongxing Erguotou/mice body weight）. Then intragastric administration of L-arabinose of four dosages（low, medium, medium-high, and high） was performed before, at the same time of, and after liquor administration. The righting reflex disappearing time and recovering time, drunk rate, and sober rate were used as the evaluating indexes. In addition, ALDH of liver was observed by ELISA Kit. The results suggested that, oral intake of L-arabinose（6 g/kg） could significantly prevent drunk of mice, and improve sober rate of mice. Besides, L-arabinose could improve the secretion of acetaldehyde dehydrogenase in mice liver. The administration of Larabinose could effectively prevent drunkenness and relieve alcoholism symptoms especially before drinking.