牙周炎对全身疾病和健康影响的研究进展

Research progress of impacts of periodontitis on systemic diseases and health

牙周炎是常见的慢性感染性疾病,可造成牙周支持组织破坏,是导致成年人失牙的最主要原因。此外,大量研究证明,牙周炎能通过龈下菌斑生物膜中的微生物及其产物引起全身炎症及免疫反应,可能成为一些全身疾病的危险因素。虽然牙周炎和全身疾病相互作用的具体生物学机制仍不清楚,但现有的一些研究证据确实证明了二者互相促进的关系。本文就牙周炎对全身疾病和健康的影响作简要阐述。

Periodontitis is a chronic infectious disease which can cause the destruction of tooth-supporting structures. It is acknowledged that periodontitis is the leading cause of tooth loss in adults. What＇s worse,emerging evidence suggests that periodontitis can elicit systemic inflammation and adaptive immune response through subgingival microorganisms in the dental biofilm. Hence,periodontitis has been recognized as a potential risk factor contributing to a wide range of systemic diseases. Although the detailed biological mechanisms are still not fully understood,some available studies do prove that a bidirectional link exists between periodontitis and systemic diseases,both of whose conditions can affect and aggravate each other. This article attempts to make a brief summary on the impacts of periodontal disease on systemic diseases and health.