蜂蜜敷料用于慢性伤口治疗效果的Meta分析

Meta-analysis of the therapeutic effect of honey dressings on chronic wounds

目的:评价蜂蜜敷料应用于慢性伤口的治疗效果。方法:通过计算机检索Pub Med,Web of Science,Cochrane Librar y,Embase,维普,中国知网及万方数据库中关于蜂蜜敷料应用于慢性伤口治疗的随机对照试验(randomized controlled trial,RCT),对符合纳入标准的研究采用Rev Man 5.3软件进行meta分析。结果:共纳入15篇RCTs,样本量共1 641例。Meta分析结果显示:与对照组敷料相比,蜂蜜敷料组具有较高的愈合率、较短的愈合时间及细菌清除时间、较轻的疼痛感受及较低的换药费用;但在细菌培养阳性率方面,差异无统计学意义(P=0.15)。结论:蜂蜜敷料可有效促进慢性伤口愈合,及时清除伤口感染,缩短慢性伤口愈合时间,是一种安全、经济、有效的治疗方法。

Objective： To evaluate the therapeutic effect of honey dressing on chronic wounds. Methods： A randomized controlled trial of Pub Med, Web of Science, Cochrane Library, Embase, VIP, CNKI and Wanfang database for chronic wound therapy was performed by computer. The Rev Man 5.3 software was used for the meta-analysis of the study which was in conformity with the inclusion criteria. Results： A total of 15 randomized controlled trials（RCTs） were included, with a total sample size of 1 641 cases. The results of Meta-analysis showed that the honey dressing group had higher healing rate, faster healing time and bacterial clearance time, less pain and lower dressing cost compared with the dressing of the control group. However, there was no significant difference in the positive rate of bacterial culture（P=0.15）. Conclusion： Honey dressing can effectively promote the healing of chronic wounds, remove wound infection in time, and shorten the healing time of chronic wounds. It is a safe, economical and effective treatment.