系统性红斑狼疮中β2微球蛋白检测的临床意义

Clinical significance of beta 2microglobulin detection in systemic lupus erythematosus

目的探讨系统性红斑狼疮(systemic lupus erythematosus SLE)患者血清β2-微球蛋白(β2-MG)水平与疾病活动及肾脏损害相关性及临床意义。方法采用放射免疫法测定155例SLE患者血清中β2-微球蛋白水平,观察其与SLE疾病活动相关性及肾脏损害的关系。结果 SLE患者中缓解期β2-MG平均水平(2.98±1.78)mg/L,活动期β2-MG平均水平(5.89±5.35)mg/L,两者比较有统计学意义P<0.01,狼疮肾炎组β2-MG平均水平(4.75±3.09)mg/L非肾炎组(3.44±2.39)mg/L,两者比较P<0.015,有统计学意义。结论β2-MG可作为判断SLE疾病活动及肾脏损害有效指标之一。

Objective To explore the clinificance of serumβ 2-microglobulin（β 2-MG） and disease activity together with renal damage in systemic lupus erythematosus（SLE） patients. Methods The levels of serumβ 2-MG were measured by rodioimmunoassay in155 patients with SLE. Results The levels of serum β 2-MG in SLE were significantly higher in active group than that of in the remisson group（5.89±5.35）mg/L VS 2.98±1.78） mg/L. The concentration of serum β 2-MG in lupus nephritis patients were significantly higher than that of non-lupus nephritis group（4.75±3.09）mg/L VS（3.44±2.39）mg/L. Conclusion Serum β 2-MG may associate with disease activity and renal damage in patients with SLE.