环状RNA及其在妇科肿瘤中的应用

Circular RNA and its application in gynecological carcinoma

环状RNA是一种共价闭合环状分子，在环状RNA微小RNA信使RNA调控轴中充当微小RNA的海绵作用，可调控基因转录及蛋白质翻译。在妇科肿瘤中，环状RNA存在差异性表达，可影响细胞的增殖、迁移、侵袭，从而发挥抑癌或促癌作用。环状RNA的稳定性、丰富性、特异性及保守性使其有望成为妇科肿瘤预测、诊断及治疗的新靶点。

Circular RNAs （circRNAs） are a class of RNA which forms covalently closed loops. They act as microRNA （miRNA） sponge in the circRNAmiRNAmRNA regulatory axis, regulating gene transcription and protein translation. CircRNAs are differently expressed in gynecological carcinoma. They can affect the proliferation, invasion and migration of gynecological tumor cells, playing a role in inhibiting or promoting cancer. CircRNAs are featured with characteristics of stabilities, abundance, specificity and conservative, making it a potential target for the prediction, diagnosis and treatment of gynecologic tumors.