子痫前期与儿童自闭症发生风险相关性Meta分析

Preeclampsia and risk of children with autism spectrum disorder:A meta-analysis

目的评价孕妇发生子痫前期(preeclampsia),其儿童发生自闭症的风险,为临床应用提供证据。方法通过计算机检索PubMed、Embase、Cochrane database、Web of Science等数据库,查找相关研究,检索时限从建库至2016年9月。对纳入的文章进行质量评价,计算比值比(OR)及95%置信区间(CI),采用Stata 12.0软件进行Meta分析。结果纳入文献24篇,包括16篇病例对照研究和8篇队列研究。纳入自闭症儿童共计81 384例,同期正常儿童7 250 091例。Meta分析结果显示:与正常孕妇的儿童相比,子痫前期孕妇的儿童自闭症发生风险更高,差异有统计学意义(OR=1.44,95%CI:1.24~1.67,P<0.01)。结论孕妇发生子痫前期,其儿童发生自闭症的风险显著增加,评价孕妇子痫前期可能对于预测儿童自闭症发生风险有一定价值。

Objective To evaluate the risk of maternal preeclampsia and children with outism spectrum disorder（ASD）so as to provide some evidence.Methods We conducted a systematic literature search in PubMed,Embase,Cochrane database and Web of Science to search related studies up to September 2016.Included literatures were evaluated.Odd ratio（OR）and 95% confidence interval（95% CI）were calculated,and statistical analysis was performed using Stata 12.0 software.Results Sixteen case-control studies and 8 cohort studies were recruited,involving 81 384 children with ASD and 7 250 091 non-autistic children at the same period.Meta-analysis results showed that the risk of incidence of children with ASD of mothers with preeclampsia was higher than that of normal pregnant women,and the difference was statistically significant（OR =1.44,95%CI：1.24-1.67,P〈0.01）.Conclusion The risk of children with ASD when mothers suffer from preeclampsia is significantly higher,and evaluating pregnant woman preeclampsia may has certain value in predicting risk of autism in children.