乳腺癌新辅助化疗后前哨淋巴结活检术的研究

Study on Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer

目的探讨对乳腺癌患者行新辅助化疗后,对前哨淋巴结(sentinel lymph nodes,SLN)活检术的可行性研究。方法回顾性分析2015年7月至2017年7月在我院就诊的37例行新辅助化疗后的乳腺癌患者作为研究对象,待检查结果显示腋窝淋巴结为阴性以后,再进行前哨淋巴结活检术,对其检出率、灵敏度、准确性、阴阳性检出率以及假阴性率进行观察。结果 37例患者中成功检出SLN的患者共32例(86.49%),其中有14例SLN阳性(43.75%),2例为仅有阳性(6.25%),18例为SLN阴性(56.25%);此外,准确率为84.38%,2例患者为假阴性,假阴性率为12.50%,灵敏度为87.50%。结论对Ⅱ、Ⅲ期乳腺癌患者行新辅助化疗后,SLNB与早期乳腺癌患者SLNB的效果类似。

Objective To investigate the feasibility of sentinel lymph node biopsy for breast cancer patients after neoadjuvant chemotherapy. Methods A retrospective analysis from July 2015 to July 2017 in our hospital 37 cases after neoadjuvant chemotherapy in breast cancer patients as the research object,the test results show that the axillary lymph nodes were negative,then the sentinel lymph node biopsy,the detection rate of observation,sensitivity,accuracy,and detection rate of yin and Yang the false negative rate. Results 37 cases were successfully detected in SLN patients with a total of 32 cases（86. 49%）,of which 14 cases were SLN positive（43. 75%）,2 cases were positive（6. 25%）,only18 cases were negative for SLN（56. 25%）; in addition,the accuracy rate was 84. 38%,2 cases were false negative,false negative rate 12. 50%,the sensitivity was 87. 50%. Conclusions After neoadjuvant chemotherapy for patients with stage II and III breast cancer,the effect of SLNB is similar to that of early breast cancer patients with SLNB.