环境中三(2,3-二溴丙基)异氰脲酸酯的研究进展

Research Progress of Tris-(2,3-Dibromopropyl) Isocyanurate in Environment

新型溴系阻燃剂三(2,3-二溴丙基)异氰脲酸酯(TBC)是一种潜在的持久性有机污染物,不仅污染环境,还可能通过生物累积和食物链传递,对生态系统产生潜在危害。该文介绍了TBC的理化特征,对比分析了环境样品中TBC不同的检测方法,综述了水、沉积物、土壤和生物体内TBC的分布和水平,结合活体/体外毒性测试结果,阐述了TBC生长发育毒性、神经毒性、细胞毒性及内分泌干扰效应。最后针对当前研究中存在的一些问题,认为未来研究应注重建立标准化的分析方法,研究TBC在环境中的迁移转化和归趋,并致力于开展低剂量TBC的全生命周期或多代暴露的慢性毒理学研究。

Tris-（2,3-dibromopropyl） isocyanurate（TBC）,a new-type brominated flame retardant（BFR）,is considered as a kind of potential POPs that threatens the ecological system through bioaccumulation and food chain transfer.This paper overviewed the physical and chemical characteristics of TBC,detection methods of TBC in environmental samples,and the occurrence,distribution and levels of TBC in waters,sediments,soils and organisms;summarized the results of in vivo and in vitro toxicity tests,and gave a brief introduction of toxicological research of TBC in terms of developmental toxicity,neurotoxicity,cytotoxicity and endocrine disrupting effects of TBC.In view of the limits of the current researches in this area,it is suggested that future studies should focus on setup of standardized analysis methods,underscore the investigation of TBC＇s migration,and transformation,as well as fate in the environment;in addition,researches on the chronic toxicology of low-dose TBC＇s in full life-cycle of organism or multi-generation exposure should be paid attention to.