肿瘤微环境刺激响应聚合物纳米递药系统的研究进展

Research Advances in Tumor Microenvironment Responsive Polymeric Nano-drug Delivery System

近年来聚合物纳米递药系统在肿瘤靶向治疗中的应用非常广泛。与正常组织不同,肿瘤组织具有低pH、高浓度还原型谷胱甘肽、局部缺氧、大量新生血管、血流灌注不规则等特异性微环境。根据肿瘤组织微环境设计的刺激响应聚合物纳米递药系统,可实现肿瘤部位的深层穿透,提高肿瘤细胞的摄取,加速胞内药物释放,进而提高抗肿瘤效果。综述肿瘤微环境刺激响应纳米递药系统的设计与构建、体内作用机制及其在肿瘤靶向治疗中的研究现状,为其由基础研究向临床应用转化提供一定参考。

Polymeric nano-drug delivery system has been widely used for tumor targeting. The microenvironment of tumor tissues, different from normal tissues, is characterized by acidic p H, abundant glutathione（GSH）, local hypoxia, extensive angiogenesis, irregular blood perfusion, etc. Polymeric nano-drug delivery system, designed on the basis of the characters of tumor microenvironment, could achieve deep penetration into tumor tissues, improved cellular uptake, accelerated intracellular drug release, thus increasing the anti-tumor efficacy. In this review, we mainly focused on the design principles and action mechanisms of tumor microenvironment responsive polymeric nano-drug delivery system, so as to provide reference for transformation from basic research to clinical practice.