期刊文献+

脂质体天然高分子水凝胶给药系统的研究进展 被引量:4

Research Progress in Liposome-in-natural Polymer Hydrogel Drug Delivery Systems
原文传递
导出
摘要 水凝胶是一种亲水性三维空间网络结构,与合成高聚物相比,天然高分子材料如壳聚糖、透明质酸、海藻酸钠等具有良好的生物相容性和生物可降解性,更适宜用作水凝胶基质。脂质体是一种由脂质双分子层形成的球形囊泡,脂质体水凝胶给药系统不仅可发挥脂质体缓控释、刺激响应性释放药物的特点,而且水凝胶屏障可提高脂质体的稳定性,药物可通过口服、注射、局部透皮等多种给药途径进入体内发挥药效,广泛用于药物传递系统和组织工程。综述多种以天然高分子材料为凝胶骨架,且其内含有载药脂质体、类脂囊泡等的水凝胶系统研究进展,对开发新型缓控释制剂、提高水溶性药物透皮吸收和生物利用度、研究智能刺激响应性给药系统等方面具有重要参考价值。 Hydrogel is a hydrophilic three-dimensional network. Compared with synthetic polymers, natural polymers such as chitosan, hyaluronic acid, sodium alginate are biocompatible and biodegradable and are more suitable as hydrogel matrices. Liposomes are vesicles formed by a lipid bilayer. Liposome-in-hydrogel drug delivery systems not only maintain the characteristics of liposomes in providing sustained, controlled and stimuli-responsive drug release but also improve the stability of liposome by the hydrogel barrier. These systems can be designed for oral administration, injection and local transdermal administration, with wide application in drug delivery systems and tissue engineering. This review covers a variety of hydrogel systems made of natural polymer materials that contain drug-loaded liposomes, niosomes and so on, which is valuable for developing novel sustained and controlled release formulations, improving permeability and bioavailability of water-soluble drugs, and researching intelligent stimuli-responsive drug delivery systems.
作者 祝浩成 栾立标 ZHU Haocheng;LUAN Libiao(Department of Pharmaceutics,China Pharmaceutical University,Nanjing 211198,China)
出处 《药学进展》 CAS 2018年第5期380-387,共8页 Progress in Pharmaceutical Sciences
关键词 脂质体水凝胶 天然高分子材料 缓控释 liposome-in-hydrogel natural polymer sustained and controlled release
  • 相关文献

参考文献3

二级参考文献21

  • 1李晓天,张丽容,王天奎,王红娟,贾欣.马钱子碱在小鼠体内的组织分布[J].中国临床药理学与治疗学,2006,11(3):342-344. 被引量:43
  • 2Zheng L, Wang X, Luo W, et al. Brucine, an effective natural eompound derived from nux-vomica,induces GI phase arrest and apptosis in IaVo cells[ J], Food Chem Toxico1,2013,58:332 - 339.
  • 3Deng XK, Yin W, Li WD,et al. The anti-tumor effects of alka- loids from the seeds of Stryvhnos nux-vomica on HepG2 ceils and its [)ssible mechanism [ J ]. J Ethnopharmacol, 2006,106 ( 2 ) : 179 - 186.
  • 4Yin W, Deng XK, Yin FZ,et al. The cytotoxicity induced by bru- cinc from the seed of Strycbmx nux-vomica proceeds via apoptosis and is mediated by eyclooxygenase 2 and caspase 3 in SMMC 7221 cells[ J ]. Food Chem Toxicol,2007,45(9 ) :1 700 - 1 708.
  • 5Amidi M, Mastrobattista E,Jiskoot W,et al. Chitosan-based deliv- ery systems for protein therapeutics and antigens [ J ]. Adv Drug Deliv Rev,2010,62( 1 ) :59 -82.
  • 6Chen MC, Mi FL, Liao ZX,et al. Recent advances in chitosan- based nanoparticles for oral delivery of macromolecules [ J ]. A&, Drug Deliv Rev,2013,65(6) :865 -879.
  • 7Zhang C, Ding Y, Yu LL,et al. Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives [ J ]. Colloids Surf B Biointerfaves, 2007,55 (2) :192 - 199.
  • 8Koo H, Min KH, Ie SC,et al. Enhanced drag-loading and thera- peutic efficacy of hydrotropic oligomer-cnnjugated glycol ehitnsan nanopacles for tumor-targeted paclitaxel delivery[ J ]. J Control Release,2013,172(3 ) :823 -831.
  • 9Chen ZP,Xiao L, Liu D,et al. Synthesis of a novel polymer cho- lesterol-poly ( ethylene glycol ) 2000-glycyrrhetinie acid ( chol- PEG-GA) and its application in brucine liposome [ J ]. J Appl Polym Sci,2012,1.?,4(6) :4 554 -4 563.
  • 10Yang CH,Huang KS,Lin PW,et al. Using a cross-flow microflu- idic chip and external cross-linking reaction for monodisperse TPP-chitosan microparticles [ J ]. Sensors Actuators B-Chem, 2007,124(2 ) :510 -516.

共引文献18

同被引文献34

引证文献4

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部