乳腺柱状细胞病变与临床病理的关系

The Relationship between the Clinicopathological and Pathological Changes of Mammary Columnar Cell

目的探讨乳腺组织柱状细胞病变与临床病理的关系。方法收集2013年~2017年我院收治的112例乳腺柱状细胞病变患者的临床病理资料,采用多个样本率(或构成比)的比较(即:R×C表的χ~2检验)及Pearson相关分析法,分析乳腺柱状细胞病变与临床病理的关系。结果乳腺柱状细胞病变一般分为:柱状细胞变、柱状细胞增生、平坦上皮非典型性。以这三种组织学分类病变严重程度为趋势,发现其与患者的年龄无统计学差异(P>0.05),但与发病部位有一定统计学差异(P<0.05),本研究发现平坦上皮非典型性病变均发生于右侧乳腺。三种组织学分类与是否伴随硬化性腺病、导管内乳头状瘤、普通型导管上皮增生、非典型导管上皮增生、导管原位癌无统计学差异(P>0.05),但与是否伴有纤维腺瘤和浸润癌有统计学差异(P<0.05),其中病变发展与是否伴有纤维腺瘤呈负相关(相关系数r=-0.985,P<0.05),与是否伴有浸润癌呈正相关(相关系数为r=0.823,P<0.05)。结论乳腺平坦上皮非典型性病变发生于右侧乳腺居多。病变发展与是否伴有纤维腺瘤呈负相关,与是否伴有浸润癌呈正相关。

Objective To investigate the relationship between columnar cell lesions of breast tissue and clinicopathology.Methods The clinical and pathological data of 112 patients with breast columnar lesions admitted to our hospital from 2013 to 2017 were collected.The comparison of multiple sample rates（or composition ratios）（ie,χ~2 test of R×C）and Pearson correlation analysis were used.The method was used to analyze the relationship between breast columnar lesions and clinical pathology.Results Breast columnar cell lesions are generally divided into：columnar cell changes,columnar cell proliferation,flat epithelial atypical.The severity of the lesions in these three histological categories was observed,and it was found to be no statistically different from the age of the patients（ P〉0.05）,However,there was a statistically significant difference with the location of the disease（ P〈0.05）.This study found that atypical epithelial lesions occurred in the right breast.Three histological classifications were associated with sclerosing adenosis,intraductal papilloma,common ductal epithelial hyperplasia,atypical ductal epithelial hyperplasia,and ductal carcinoma in situ,there was no statistical difference（P〉0.05）,but it was statistically different from whether there was fibroadenomas and invasive carcinoma（ P 0.05）.The development of lesions was negatively correlated with fibroadenomas（correlation coefficient r=-0.985,P〈0.05）,positively correlated with invasive carcinoma（correlation coefficient was r=0.823,P〈0.05）.Conclusion Atypical lesions of the flat epithelium of the breast occur mostly in the right breast.The development of the lesion was negatively correlated with fibroid adenoma and positively associated with invasive carcinoma.