呼出气一氧化氮浓度检测在儿童咳嗽变异性哮喘中的应用

Determination of Exhalation Nitric Oxide Concentration in Children with Cough Variant Asthma

目的探讨Fe NO检测在儿童咳嗽变异性哮喘中的临床价值。方法选择2016年3月~2017年3月在我院确诊为CVA的患儿80例及健康儿童40例作为研究对象,比较两组儿童Fe NO水平,比较Fe NO正常的CVA患儿与Fe NO升高患儿的皮肤点刺结果、肺功能,分析CVA患儿Fe NO水平与肺功能的相关性。结果 CVA患儿Fe NO水平高于健康儿童,差异有统计学意义(P<0.05)。同Fe NO正常的CVA患儿相比,Fe NO升高的CVA患儿拥有更高的体重指数,皮肤点刺阳性率更高,强度更强,差异有统计学意义(P<0.05),但两组患儿肺功能无统计学差异,CVA患儿Fe NO水平与肺功能无相关性(P>0.05)。结论Fe NO可以辅助诊断CVA,但不能作为评估病情严重程度的指标。

Objective To investigate the clinical value of Fe NO detection in children with cough variant asthma.Methods From March 2016 to March 2017,80 children with CVA diagnosed in our hospital and 40 healthy children were selected as study subjects.The levels of Fe NO in the two groups were compared,and the results of skin prick and pulmonary function were compared between the CVA children with normal Fe NO and the children with elevated Fe NO.To analyze the correlation between Fe NO level and lung function in children with CVA.Results Fe NO level in CVA children was higher than that in healthy children,the difference was statistically significant（P〈0.05）.Compared with the CVA children with normal Fe NO,CVA patients with elevated Fe NO had higher body mass index,higher skin prick positive rate and stronger intensity,the difference was statistically significant（ P〈0.05）,but there was no significant correlation between Fe NO level and lung function in CVA children（ P〉0.05）.Conclusion Fe NO can assist in the diagnosis of CVA,but it can not be used as an index to evaluate the severity of the disease.