空腹血糖与糖化血红蛋白在糖尿病早期诊断中的应用价值

Application value of fasting blood glucose and glycosylated hemoglobin in early diagnosis of diabetes mellitus

目的探讨空腹血糖(FBG)与糖化血红蛋白(GHb)在糖尿病(DM)早期诊断中的应用价值。方法选取2016年10月—2017年10月湖南省儿童医院收治的300例早期DM患儿作为研究对象,分别测定其FBG和GHb,以口服糖耐量试验结果为参考标准,对比两者的检测结果。结果 FBG和GHb在DM早期的检出率均较高,差异无统计学意义[FBG:98.33%(295/300),GHb:99.00%(297/300);χ~2=0.170,P=0.680];FBG和GHb在DM早期诊断中的敏感度、特异度、准确度也均较高[敏感度:99.04%(95%CI=0.840~0.974)、99.53%(95%CI=0.843~0.974),特异度:93.41%(95%CI=0.814~0.948)、96.63%(95%CI=0.816~0.957),准确度:96.33%(95%CI=0.805~0.939)、98.67%(95%CI=0.808~0.948)],差异均无统计学意义(均P>0.05)。结论在DM早期诊断中,FBG和GHb均可取得较为理想的诊断结果,值得在今后临床诊断工作中推广使用。

Objective To explore the value of fasting plasma glucose（FBG） and glycosylated hemoglobin（GHb） in the early diagnosis of diabetes mellitus（DM）. Methods From October 2016 to October 2017,three hundred children with early DM admitted to the Children＇s Hospital of Hunan Province were selected as subjects. The FBG and GHb were determined respectively. The results of the oral glucose tolerance test were used as reference standards to compare the results of the two tests. Results The detection rates of FBG and GHb in the early stage of DM were high, and the differences were not statistically significant [FBG： 98.33%（295/300）, GHb： 99.00%（297/300）; χ2 = 0.170, P = 0.680]; The sensitivity, specificity and accuracy of FBG and GHb in early diagnosis of DM were also relatively high [sensitivity： 99.04%（95%CI = 0.840-0.974）, 99.53%（95%CI = 0.843-0.974）, specificity： 93.41%（95%CI = 0.814-0.948）, 96.63%（95%CI = 0.816-0.957）, accuracy： 96.33%（95%CI = 0.805-0.939）, 98.67%（95%CI = 0.808-0.948）], and there were no statistical significant differences in comparisons between them（all P〈0.05） respectively. Conclusion In the early diagnosis of DM, FBG and GHb can achieve ideal diagnostic results, which is worthy to be promoted in clinical diagnosis.