亚胺培南/西司他丁钠致癫痫的临床分析及治疗

Clinical Analysis and Treatment of Epilepsy Induced by Imipenem/Cilastatin Sodium

目的:探讨亚胺培南/西司他丁钠致癫痫发作的防治措施。方法:从1例肺癌合并肺部感染患者使用亚胺培南/西司他丁钠临床病例出发,结合文献分析癫痫的发生机制及治疗方案。结果:该例患者用药结束6小时癫痫发作,给予地西泮10 mg肌注及停药处理,癫痫缓解。结论:癫痫为亚胺培南/西司他丁钠神经系统严重不良反应之一,应加强重视。

Objective： To explore the prevention and treatment of epilepsy induced by Imipenem/Cilastatin Sodium. Methods： One clinical case was selected of a patient with lung cancer accompanied with pulmonary infection who was given Imipenem/Cilastatin Sodium. The occurrence mechanism and therapeutic method of epilepsy were analyzed based on the literature review. Results： The patient suffered the epilepsy six hours after Imipenem/Cilastatin Sodium was used. After 10 mg diazepam was given through intramuscular injection and Imipenem/Cilastatin Sodium was stopped, the patient＇s epilepsy was relieved. Conclusion： Epilepsy is one of the serious adverse reactions of Imipenem/Cilastatin Sodium in the nervous system and proper importance should be attached to it.