作为脑出血后脑损伤标志物的血清S100B

Serum S100B as a brain injury marker after intracerebral hemorrhage

脑出血患者脑脊液和血液S100B水平显著增高，与卒中鉴别、血脑屏障破坏、血肿体积、脑水肿、神经功能缺损程度和转归相关。因此，S100B有望用于脑出血的诊断、评估损伤和转归甚至治疗靶点的生物标志物。

Cerebrospinal fluid and level of blood S100B protein are significantly higher in patients with intracerebral hemorrhage, which are associated the differentiation of stroke, damage of blood-brain barrier, hematoma volume, brain edema, degree of nerve function defect, and outcomes. Therefore, S100B is expected to be used in the diagnosis of intracerehral hemorrhage, assessment of injury and outcomes, and even as a biomarker of therapeutic targets.