Nogo-A及其受体在阿尔茨海默病中的作用

Role of Nogo-A and Nogo-A receptors in Alzheimer's disease

Nogo-A是一种重要的髓鞘相关生长抑制因子,在成体动物中枢神经系统损伤再生中发挥了关键的抑制作用。近年来许多研究表明,Nogo-A及其受体NgR可以影响淀粉样蛋白Aβ的代谢,其下游的ROCK激酶可以影响Aβ、tau蛋白的水平以及血脑屏障的通透性,这些均提示Nogo-A及其受体与阿尔茨海默病(AD)的发病机制有着密切的联系。此外,最近的研究还发现了Nogo-A的另外两种受体Pir B和S1PR2,可能为Nogo-A在神经系统疾病中的作用提供新的研究方向。我们将着重阐释Nogo-A及其受体的基本结构和功能的新发现,以及其在AD中的作用等方面的最新研究进展。

Nogo-A is an important myelin associated inhibitory factor,which creates a critical barrier to the central nervous system regeneration after injury. Recent research shows that Nogo-A/Nogo-A receptors can affect the metabolism of amyloid-β-protein（ Aβ）,and its downstream ROCK kinase. It can modulate the level of Aβ and tau protein,as well as the permeability of blood brain barrier. These findings suggest that Nogo-A/Nogo-A receptors have a close relationship with Alzheimer＇s disease（ AD）. Moreover,two new receptors of Nogo-A,Pir B and S1 PR2,have been identified recently. The identification of these two receptors may provide new insight into the mechanism of Nogo-A involving in the progress of central nervous diseases. we focuses on the up-to-date knowledge of the basic structure and function of Nogo-A/Nogo-A receptors and their role in AD pathogenesis.