荆芥防风对溃疡性结肠炎治疗效果的影响

Effect of Jingjie and Fangfeng in the Treatment of Ulcerative Colitis

目的 ：探讨荆芥、防风在溃疡性结肠炎湿热蕴结证、脾肾两虚证治疗中的作用。方法 ：观察因溃疡性结肠炎就诊且中医证型为湿热蕴结证、脾肾两虚证的患者84例,随机分为观察组与对照组各42例,两组根据证型予溃结Ⅰ号方或溃结Ⅱ号方,观察组在对照组原方基础上加荆芥、防风各10 g,服药周期为14 d。分析对比两组治疗前后腹泻、腹痛、黏液血便评分及中医证候积分。结果：治疗前两组患者腹泻、腹痛、黏液血便评分及中医证候积分比较差异无统计学意义（P〉0.05）。治疗后与治疗前比较,两组腹泻、腹痛、黏液血便评分及中医证候积分均有下降,且观察组症状改善优于对照组（P〈0.05）。结论：荆芥、防风对溃疡性结肠炎湿热蕴结证、脾肾两虚证的症状改善具有增效作用。

Objective：To determine the synergism of Jingjie and Fangfeng in the treatment of ulcerative colitis（UC） with accumulation of damp and heat and deficiency of both spleen and kidney. Methods：Eighty four patients with UC of accumulation of damp and heat and deficiency of both spleen and kidney were randomly divided into the observation group and control group,42 cases in each group. The control group was given Kuijie I formula or Kuijie II formula,according to syndrom,and the observation group was given Kuijie I formula and Kuijie II formula plus Jingjie 10 gram and Fangfeng 10 gram. The medication lasted for 14 days. The two groups were compared before and after treatment on diarrhea,abdominal pain,mucohemorrhage scores and traditional Chinese medicine（TCM） syndrome scores. Results：There was no satistically significant on diarrhea,abdominal pain,mucohemorrhage score and TCM syndrome score between the two groups before the treatment（P〉0.05）. After the treatment,the diarrhea,abdominal pain,mucohemorrhage scores and TCM syndrome scores of both groups were lower than those before the treatment,and the observation group was better than the control group on symptom improvement（P〈0.05）. Conclusion：Jingjie and Fangfeng have a synergistic effect to relieve the symptoms of UC with accumulation of damp and heat,and deficiency of both spleen and kidney.