血清胆红素水平与2型糖尿病血管病变相关性的研究

Relationship between serum bilirubin levels and vascular lesions in type 2 diabetes mellitus

目的探讨血清胆红素水平与2型糖尿病血管病变是否相关。方法本课题将2017年入住我院内分泌科的糖尿病患者分为无血管病变组(0组)、单纯视网膜病变组或单纯颈动脉病变组(1组)、两种血管病变组(2组),比较三组间胆红素水平差异。最后对三组进行多因素Logistic回归分析,了解胆红素水平是否与血管病变程度相关。结果 0组与1组、0组与2组的总胆红素、间接胆红素水平比较,具有显著性差异(P<0.01)。Logistic相关分析提示总胆红素、间接胆红素、直接胆红素水平均与糖尿病患者血管病变严重程度无相关性。结论胆红素下降可能并不是血管病变的原因,胆红素作为内源性抗氧化剂,它的下降是糖尿病血管病变抗氧化应激增强的结果。

Objective To understand whether serum bilirubin levels are associated with vascular lesions in type 2 dia- betes. Methods In this study, the diabetic patients admitted to our department of endocrinology in 2017 were divided into avascular disease group（group 0）, simple retinopathy group or simple carotid artery disease group（group 1）, and two vascular disease groups（group 2）. Compared differences in levels of bilirubin between the three groups. Finally, 3 groups were subjected to multivariate logistic regression analysis to understand whether bilirubin levels were related to the degree of vascular lesions. Results There were significant differences in total bilirubin and indirect bilirubin between group 0 and group 1, 0 and 2（P〈0.01）. Logistic correlation analysis revealed that there was no correlation between total bilirubin, indirect bilirubin, and direct bilirubin levels and the severity of vascular lesions in diabetic patients. Conclusion The decrease of bilirubin may not be the cause of vascular lesions. Bilirubin is an endogenous antioxidant and its decline is the result of enhanced antioxidative stress in diabetic vascular lesions.