基于多尺度的生物医用高聚物降解强度模型

Degradation Strength Modeling of Medical Biodegradable Polyesters Based on Multi-Scale Modeling

生物医用高聚物由于其良好的性能与降解性,在医学上有广泛的应用前景。降解过程中的强度变化直接影响到应用情况,而降解过程的复杂性使得强度预测困难。文中在分析强度影响因素的前提下,首先由公式推导证明代表性强度模型的不适用性,然后在生物医用高聚物的降解多尺度模型基础上提出针对降解变化过程中出现的异质相的异相强度模型,不同相采用不同的强度公式,并与多尺度模型耦合计算,计算结果与实验数据拟合得很好,表明文中提出的方法正确可行。

Biodegradation polyester has a wide range of application prospects in medicine due to their good properties and biodegradability. The change of strength during the degradation process directly affects the situation of application,and the complexity of degradation makes the strength prediction more difficult. In this paper,after analyzing the influence factors of strength,the non-applicability of the representative strength model was proved by formula deduction,and then a heterogeneous phase strength model based on the multi-scale model of the degradation of biodegradation polyesters was proposed. Different strength equations were used in different polymer phases. The proposed strength model is coupled with the multi-scale model,the calculated results fit with experimental data very well,which indicates that the method proposed in this paper is correct and feasible.