高血压与中心性肥胖对心脑血管疾病的联合作用

Combined effects of hypertension and central obesity on the risk of cardio-cerebrovascular diseases

目的探讨高血压合并中心性肥胖患者心脑血管疾病的发病危险性。方法采用横断面调查的方法,于2016年3~4月期间,共调查苏州市高新区常住居民9 984人,收集其人口统计学、疾病史以及生活方式资料,并进行体格检查以及生化指标检查。采用Logistic回归模型分析高血压合并中心性肥胖与心脑血管疾病的关系。结果在9 984名研究对象中,患心脑血管疾病者共396人(患病率3.97%),其中冠心病243人(患病率为2.43%),脑卒中178人(患病率为1.78%)。经多因素调整后,与腰围及血压均正常者相比,高血压合并中心性肥胖者患脑卒中、冠心病以及心脑血管疾病的OR及95%CI值分别为3.10(1.78~5.40),2.56(1.61~4.07)和3.06(2.10~4.45)(均有P<0.05)。结论高血压合并中心性肥胖可能会增加心脑血管疾病的患病风险。

Objective To evaluate the combined effects of hypertension and central obesity on the risk of cardiocerebrovascular diseases. Methods A total of 9 984 residents from Suzhou New District were recruited as study subjects in our cross-sectional study from March to April 2016. Demographic data, disease and lifestyle history were collected. Physical and biochemical indicators were examined for all individuals. Logistic regression model was used to analyze the association between central obesity combined with hypertension and cardio-cerebrovascular diseases. Results Among 9 984 participants, 396 people suffered from cardio-cerebrovascular diseases （period prevalence ： 3.97% ） , including 243 coro- nary heart disease patients （period prevalence： 2.43% ）, and 178 stroke patients （period prevalence： 1.78% ）. Compared with normotensives with non-central obesity, in a multivariate adjusted model, the OR and 95% CI of stroke, coronary heart disease and cardio-cerebrovascular diseases for hypertensives with central obesity were 3.10（ 1.78-5. 40）, 2.56（ 1.61-4. 07） and 3.06（2.10-4.45）, respectively （all P〈0.05）. Conclusion These results indicate that the coexistence of hy- pertension and central obesity may increase the risk of cardio-cerebrovascular diseases.