血清甘胆酸在酒精性及乙型肝炎性肝硬化患者中的临床意义

The clinical value of serum cholyglycine in alcoholic and hepatitis B cirrhosis

目的 分析酒精性肝硬化、乙型肝炎性肝硬化患者及健康人群血清中甘胆酸含量的差异性，比较分析血清甘胆酸相对于传统肝硬化血清学标志物的优越性。 方法 通过全自动生化分析仪采用均相酶免疫法测定49例酒精性肝硬化患者、45例乙型肝炎性肝硬化患者与30例健康人群血清样本中甘胆酸（CG）的水平，同时测定样本血清中总胆红素（TBIL）、谷氨酸丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆汁酸（TBA）、γ谷酰转肽酶（GGT）常规肝功能指标。 结果 酒精性肝硬化与乙型肝炎性肝硬化患者血清CG水平相对于健康人群均明显升高，差异具有统计学意义（ P 〈0.05），但酒精性肝硬化患者与乙型肝炎性肝硬化患者血清CG含量差异无统计学差异（ P 〉0.05）；同时重度肝硬化患者的CG水平显著高于轻度肝硬化患者，差异具有统计学意义（ P 〈0.05）；酒精性肝硬化患者AST/ALT比值较乙型肝炎性肝硬化患者AST/ALT比值高，差异具有统计学意义（ P ＜0.05）；甘胆酸阳性率高达88%，较传统肝功能相关血清学标志物（TBA、TBIL、ALT、GGT、AST）阳性率更高。 结论 检测肝硬化患者血清甘胆酸（CG）水平对于疾病的及时诊断、病情的评估和预后有重要的临床价值，能帮助临床医生更加准确的判断患者疾病类型。

Objective： To analyze the concentration of serum Cholyglycine（CG） between patients with alcoholic cirrhosis,Hepatitis B cirrhosis and healthy population,and compare the superiority of Cholyglycine with traditional serological markers of cirrhosis. Methods ： Using the automatic biochemical analyzer to detect concentration of Cholyglycine（CG） by homogeneous enzyme immunoassay in 49 cases of patients with alcoholic cirrhosis,45 cases of hepatitis B cirrhosis patients and 30 healthy persons.The levels of total bilirubin（TBIL）,glutamic acid alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bile acid（TBA） and gamma glutamyl transpeptidase（GGT） were measured as routine liver function index. Results ： Compared with healthy controls,the CG levels were significantly increased in alcoholic cirrhosis and hepatitis B cirrhosis patients（ P 〈0.05）,while there was no significant difference between alcoholic cirrhosis and hepatitis B cirrhosis patients（ P 〉0.05）.At the same time the level of CG with severe cirrhosis was significantly higher than that of mild cirrhosis（ P 〈0.05）.Compared with hepatitis B cirrhosis,the ratio of AST/ALT is higher in patients with alcoholic cirrhosis（ P 〈0.05）.The positive rate of CG was up to 88% in cirrhosis,which was higher than them within traditional serological markers（TBA、TBIL、ALT、GGT、AST）. Conclusion ： Detection of serum CG in patients with cirrhosis has important clinical value for timely diagnosis,assessment and prognosis of disease,which can help clinicians to more accurately diagnose disease types.